Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of γ-lactams

Christopher Hulme, Kevin Moriarty, Fu Chih Huang, Jonathon Mason, Dan McGarry, Richard Labaudiniere, John Souness, Stevan Djuric

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

This communication describes the synthesis and in vitro evaluation of a novel potent series of phosphodiesterase type (IV) (PDE IV) inhibitors. Several of the quaternary substituted lactams presented possess low nanomolar IC50's for PDE IV inhibition.

Original languageEnglish (US)
Pages (from-to)399-404
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number4
DOIs
Publication statusPublished - Feb 17 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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