Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles

Christopher Hulme, Gregory B. Poli, Fu Chih Huang, John E. Souness, Stevan W. Djuric

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50's for PDE4 inhibition are reported.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number2
DOIs
StatePublished - Jan 20 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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