Quinidine-Digoxin Interaction

Teut Risler, Uwe Peters, Bernd Grabensee, Ludger Seipel, St George T. Lee, Karl David Straub, Knud E. Pedersen, Steffen Hvidt, J. Robert Powell, Paul E Fenster, W. David Hager, Penelope Graves, Michael Wandell, Kenneth Conrad, W. Doering

Research output: Contribution to journalLetter

7 Citations (Scopus)

Abstract

To the Editor: We read with great interest Dr. Doering's article on the digoxin-quinidine interaction in the August 23 issue. Although we agree with most of his findings, we would like to present some additional results from our study1 that suggest a different mechanism of the digoxin-quinidine interaction. In our study serum concentrations of digoxin and quinidine as well as urinary levels of digoxin were measured in 11 volunteers under steady-state conditions (0.375 mg of digoxin per day). The group's mean (±S.D.) serum digoxin concentration was 0.75±0.2 ng per milliliter before and 1.2±0.4 ng per milliliter after (P<0.0001) concomitant administration.

Original languageEnglish (US)
Pages (from-to)175-177
Number of pages3
JournalNew England Journal of Medicine
Volume302
Issue number3
DOIs
StatePublished - Jan 17 1980
Externally publishedYes

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Quinidine
Digoxin
Serum
Volunteers

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Risler, T., Peters, U., Grabensee, B., Seipel, L., Lee, S. G. T., Straub, K. D., ... Doering, W. (1980). Quinidine-Digoxin Interaction. New England Journal of Medicine, 302(3), 175-177. https://doi.org/10.1056/NEJM198001173020314

Quinidine-Digoxin Interaction. / Risler, Teut; Peters, Uwe; Grabensee, Bernd; Seipel, Ludger; Lee, St George T.; Straub, Karl David; Pedersen, Knud E.; Hvidt, Steffen; Powell, J. Robert; Fenster, Paul E; Hager, W. David; Graves, Penelope; Wandell, Michael; Conrad, Kenneth; Doering, W.

In: New England Journal of Medicine, Vol. 302, No. 3, 17.01.1980, p. 175-177.

Research output: Contribution to journalLetter

Risler, T, Peters, U, Grabensee, B, Seipel, L, Lee, SGT, Straub, KD, Pedersen, KE, Hvidt, S, Powell, JR, Fenster, PE, Hager, WD, Graves, P, Wandell, M, Conrad, K & Doering, W 1980, 'Quinidine-Digoxin Interaction', New England Journal of Medicine, vol. 302, no. 3, pp. 175-177. https://doi.org/10.1056/NEJM198001173020314
Risler T, Peters U, Grabensee B, Seipel L, Lee SGT, Straub KD et al. Quinidine-Digoxin Interaction. New England Journal of Medicine. 1980 Jan 17;302(3):175-177. https://doi.org/10.1056/NEJM198001173020314
Risler, Teut ; Peters, Uwe ; Grabensee, Bernd ; Seipel, Ludger ; Lee, St George T. ; Straub, Karl David ; Pedersen, Knud E. ; Hvidt, Steffen ; Powell, J. Robert ; Fenster, Paul E ; Hager, W. David ; Graves, Penelope ; Wandell, Michael ; Conrad, Kenneth ; Doering, W. / Quinidine-Digoxin Interaction. In: New England Journal of Medicine. 1980 ; Vol. 302, No. 3. pp. 175-177.
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AU - Grabensee, Bernd

AU - Seipel, Ludger

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AU - Straub, Karl David

AU - Pedersen, Knud E.

AU - Hvidt, Steffen

AU - Powell, J. Robert

AU - Fenster, Paul E

AU - Hager, W. David

AU - Graves, Penelope

AU - Wandell, Michael

AU - Conrad, Kenneth

AU - Doering, W.

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AB - To the Editor: We read with great interest Dr. Doering's article on the digoxin-quinidine interaction in the August 23 issue. Although we agree with most of his findings, we would like to present some additional results from our study1 that suggest a different mechanism of the digoxin-quinidine interaction. In our study serum concentrations of digoxin and quinidine as well as urinary levels of digoxin were measured in 11 volunteers under steady-state conditions (0.375 mg of digoxin per day). The group's mean (±S.D.) serum digoxin concentration was 0.75±0.2 ng per milliliter before and 1.2±0.4 ng per milliliter after (P<0.0001) concomitant administration.

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