Quinidine-Digoxin Interaction

Teut Risler, Uwe Peters, Bernd Grabensee, Ludger Seipel, St George T. Lee, Karl David Straub, Knud E. Pedersen, Steffen Hvidt, J. Robert Powell, Paul E. Fenster, W. David Hager, Penelope Graves, Michael Wandell, Kenneth Conrad, W. Doering

Research output: Contribution to journalLetter

7 Scopus citations

Abstract

To the Editor: We read with great interest Dr. Doering's article on the digoxin-quinidine interaction in the August 23 issue. Although we agree with most of his findings, we would like to present some additional results from our study1 that suggest a different mechanism of the digoxin-quinidine interaction. In our study serum concentrations of digoxin and quinidine as well as urinary levels of digoxin were measured in 11 volunteers under steady-state conditions (0.375 mg of digoxin per day). The group's mean (±S.D.) serum digoxin concentration was 0.75±0.2 ng per milliliter before and 1.2±0.4 ng per milliliter after (P<0.0001) concomitant administration.

Original languageEnglish (US)
Pages (from-to)175-177
Number of pages3
JournalNew England Journal of Medicine
Volume302
Issue number3
DOIs
StatePublished - Jan 17 1980
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Risler, T., Peters, U., Grabensee, B., Seipel, L., Lee, S. G. T., Straub, K. D., Pedersen, K. E., Hvidt, S., Powell, J. R., Fenster, P. E., Hager, W. D., Graves, P., Wandell, M., Conrad, K., & Doering, W. (1980). Quinidine-Digoxin Interaction. New England Journal of Medicine, 302(3), 175-177. https://doi.org/10.1056/NEJM198001173020314