Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones

Hexin Xie, Aiguo Song, Xinshuai Zhang, Xiaobei Chen, Hao Li, Chunquan Sheng, Wei Wang

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soós' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.

Original languageEnglish (US)
Pages (from-to)928-930
Number of pages3
JournalChemical Communications
Volume49
Issue number9
DOIs
StatePublished - Jan 2 2013
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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