Race and ancestry in biomedical research: Exploring the challenges

Timothy Caulfield, Stephanie M. Fullerton, Sarah E. Ali-Khan, Laura Arbour, Esteban G. Burchard, Richard S. Cooper, Billie Jo Hardy, Simrat Harry, Robyn Hyde-Lay, Jonathan Kahn, Rick A Kittles, Barbara A. Koenig, Sandra S J Lee, Michael Malinowski, Vardit Ravitsky, Pamela Sankar, Stephen W. Scherer, Béatrice Séguin, Darren Shickle, Guilherme Suarez-KurtzAbdallah S. Daar

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The use of race in biomedical research has, for decades, been a source of social controversy. However, recent events, such as the adoption of racially targeted pharmaceuticals, have raised the profile of the race issue. In addition, we are entering an era in which genomic research is increasingly focused on the nature and extent of human genetic variation, often examined by population, which leads to heightened potential for misunderstandings or misuse of terms concerning genetic variation and race. Here, we draw together the perspectives of participants in a recent interdisciplinary workshop on ancestry and health in medicine in order to explore the use of race in research issue from the vantage point of a variety of disciplines. We review the nature of the race controversy in the context of biomedical research and highlight several challenges to policy action, including restrictions resulting from commercial or regulatory considerations, the difficulty in presenting precise terminology in the media, and drifting or ambiguous definitions of key terms.

Original languageEnglish (US)
Article numbergm8
JournalGenome Medicine
Volume1
Issue number1
DOIs
StatePublished - Jan 21 2009
Externally publishedYes

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Biomedical Research
Medical Genetics
Research
Terminology
Medicine
Education
Health
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this

Caulfield, T., Fullerton, S. M., Ali-Khan, S. E., Arbour, L., Burchard, E. G., Cooper, R. S., ... Daar, A. S. (2009). Race and ancestry in biomedical research: Exploring the challenges. Genome Medicine, 1(1), [gm8]. https://doi.org/10.1186/gm8

Race and ancestry in biomedical research : Exploring the challenges. / Caulfield, Timothy; Fullerton, Stephanie M.; Ali-Khan, Sarah E.; Arbour, Laura; Burchard, Esteban G.; Cooper, Richard S.; Hardy, Billie Jo; Harry, Simrat; Hyde-Lay, Robyn; Kahn, Jonathan; Kittles, Rick A; Koenig, Barbara A.; Lee, Sandra S J; Malinowski, Michael; Ravitsky, Vardit; Sankar, Pamela; Scherer, Stephen W.; Séguin, Béatrice; Shickle, Darren; Suarez-Kurtz, Guilherme; Daar, Abdallah S.

In: Genome Medicine, Vol. 1, No. 1, gm8, 21.01.2009.

Research output: Contribution to journalArticle

Caulfield, T, Fullerton, SM, Ali-Khan, SE, Arbour, L, Burchard, EG, Cooper, RS, Hardy, BJ, Harry, S, Hyde-Lay, R, Kahn, J, Kittles, RA, Koenig, BA, Lee, SSJ, Malinowski, M, Ravitsky, V, Sankar, P, Scherer, SW, Séguin, B, Shickle, D, Suarez-Kurtz, G & Daar, AS 2009, 'Race and ancestry in biomedical research: Exploring the challenges', Genome Medicine, vol. 1, no. 1, gm8. https://doi.org/10.1186/gm8
Caulfield T, Fullerton SM, Ali-Khan SE, Arbour L, Burchard EG, Cooper RS et al. Race and ancestry in biomedical research: Exploring the challenges. Genome Medicine. 2009 Jan 21;1(1). gm8. https://doi.org/10.1186/gm8
Caulfield, Timothy ; Fullerton, Stephanie M. ; Ali-Khan, Sarah E. ; Arbour, Laura ; Burchard, Esteban G. ; Cooper, Richard S. ; Hardy, Billie Jo ; Harry, Simrat ; Hyde-Lay, Robyn ; Kahn, Jonathan ; Kittles, Rick A ; Koenig, Barbara A. ; Lee, Sandra S J ; Malinowski, Michael ; Ravitsky, Vardit ; Sankar, Pamela ; Scherer, Stephen W. ; Séguin, Béatrice ; Shickle, Darren ; Suarez-Kurtz, Guilherme ; Daar, Abdallah S. / Race and ancestry in biomedical research : Exploring the challenges. In: Genome Medicine. 2009 ; Vol. 1, No. 1.
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