Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery: A randomized trial

Steven Goldman, Gulshan K. Sethi, William Holman, Hoang Thai, Edward McFalls, Herbert B. Ward, Rosemary F. Kelly, Birger Rhenman, Gareth H. Tobler, Faisal G. Bakaeen, Joseph Huh, Ernesto Soltero, Mohammed Moursi, Miguel Haime, Michael Crittenden, Vigneshwar Kasirajan, Michelle Ratliff, Stewart Pett, Anand Irimpen, William GunnarDonald Thomas, Stephen Fremes, Thomas Moritz, Domenic Reda, Lynn Harrison, Todd H. Wagner, Yajie Wang, Lori Planting, Meredith Miller, Yvette Rodriguez, Elizabeth B Juneman, Douglass Morrison, Mary Kaye Pierce, Sandra Kreamer, Mei Chiung Shih, Kelvin Lee

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Context: Arterial grafts are thought to be better conduits than saphenous vein grafts for coronary artery bypass grafting (CABG) based on experience with using the left internal mammary artery to bypass the left anterior descending coronary artery. The efficacy of the radial artery graft is less clear. Objective: To compare 1-year angiographic patency of radial artery grafts vs saphenous vein grafts in patients undergoing elective CABG. Design, Setting, and Participants: Multicenter, randomized controlled trial conducted from February 2003 to February 2009 at 11 Veterans Affairs medical centers among 757 participants (99% men) undergoing first-time elective CABG. Interventions: The left internal mammary artery was used to preferentially graft the left anterior descending coronary artery whenever possible; the best remaining recipient vessel was randomized to radial artery vs saphenous vein graft. Main Outcome Measures: The primary end point was angiographic graft patency at 1 year after CABG. Secondary end points included angiographic graft patency at 1 week after CABG, myocardial infarction, stroke, repeat revascularization, and death. Results: Analysis included 733 patients (366 in the radial artery group, 367 in the saphenous vein group). There was no significant difference in study graft patency at 1 year after CABG (radial artery, 238/266; 89%; 95% confidence interval [CI], 86%-93%; saphenous vein, 239/269; 89%; 95% CI, 85%-93%; adjusted OR, 0.99; 95% CI, 0.56-1.74; P=.98). There were no significant differences in the secondary end points. Conclusion: Among Veterans Affairs patients undergoing first-time elective CABG, the use of a radial artery graft compared with saphenous vein graft did not result in greater 1-year patency. Trial Registration: clinicaltrials.gov Identifier: NCT00054847

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalJournal of the American Medical Association
Volume305
Issue number2
DOIs
StatePublished - Jan 12 2011

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Radial Artery
Saphenous Vein
Coronary Artery Bypass
Transplants
Mammary Arteries
Veterans
Confidence Intervals
Coronary Vessels
Randomized Controlled Trials
Stroke
Myocardial Infarction
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Medicine(all)

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Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery : A randomized trial. / Goldman, Steven; Sethi, Gulshan K.; Holman, William; Thai, Hoang; McFalls, Edward; Ward, Herbert B.; Kelly, Rosemary F.; Rhenman, Birger; Tobler, Gareth H.; Bakaeen, Faisal G.; Huh, Joseph; Soltero, Ernesto; Moursi, Mohammed; Haime, Miguel; Crittenden, Michael; Kasirajan, Vigneshwar; Ratliff, Michelle; Pett, Stewart; Irimpen, Anand; Gunnar, William; Thomas, Donald; Fremes, Stephen; Moritz, Thomas; Reda, Domenic; Harrison, Lynn; Wagner, Todd H.; Wang, Yajie; Planting, Lori; Miller, Meredith; Rodriguez, Yvette; Juneman, Elizabeth B; Morrison, Douglass; Pierce, Mary Kaye; Kreamer, Sandra; Shih, Mei Chiung; Lee, Kelvin.

In: Journal of the American Medical Association, Vol. 305, No. 2, 12.01.2011, p. 167-174.

Research output: Contribution to journalArticle

Goldman, S, Sethi, GK, Holman, W, Thai, H, McFalls, E, Ward, HB, Kelly, RF, Rhenman, B, Tobler, GH, Bakaeen, FG, Huh, J, Soltero, E, Moursi, M, Haime, M, Crittenden, M, Kasirajan, V, Ratliff, M, Pett, S, Irimpen, A, Gunnar, W, Thomas, D, Fremes, S, Moritz, T, Reda, D, Harrison, L, Wagner, TH, Wang, Y, Planting, L, Miller, M, Rodriguez, Y, Juneman, EB, Morrison, D, Pierce, MK, Kreamer, S, Shih, MC & Lee, K 2011, 'Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery: A randomized trial', Journal of the American Medical Association, vol. 305, no. 2, pp. 167-174. https://doi.org/10.1001/jama.2010.1976
Goldman, Steven ; Sethi, Gulshan K. ; Holman, William ; Thai, Hoang ; McFalls, Edward ; Ward, Herbert B. ; Kelly, Rosemary F. ; Rhenman, Birger ; Tobler, Gareth H. ; Bakaeen, Faisal G. ; Huh, Joseph ; Soltero, Ernesto ; Moursi, Mohammed ; Haime, Miguel ; Crittenden, Michael ; Kasirajan, Vigneshwar ; Ratliff, Michelle ; Pett, Stewart ; Irimpen, Anand ; Gunnar, William ; Thomas, Donald ; Fremes, Stephen ; Moritz, Thomas ; Reda, Domenic ; Harrison, Lynn ; Wagner, Todd H. ; Wang, Yajie ; Planting, Lori ; Miller, Meredith ; Rodriguez, Yvette ; Juneman, Elizabeth B ; Morrison, Douglass ; Pierce, Mary Kaye ; Kreamer, Sandra ; Shih, Mei Chiung ; Lee, Kelvin. / Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery : A randomized trial. In: Journal of the American Medical Association. 2011 ; Vol. 305, No. 2. pp. 167-174.
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abstract = "Context: Arterial grafts are thought to be better conduits than saphenous vein grafts for coronary artery bypass grafting (CABG) based on experience with using the left internal mammary artery to bypass the left anterior descending coronary artery. The efficacy of the radial artery graft is less clear. Objective: To compare 1-year angiographic patency of radial artery grafts vs saphenous vein grafts in patients undergoing elective CABG. Design, Setting, and Participants: Multicenter, randomized controlled trial conducted from February 2003 to February 2009 at 11 Veterans Affairs medical centers among 757 participants (99{\%} men) undergoing first-time elective CABG. Interventions: The left internal mammary artery was used to preferentially graft the left anterior descending coronary artery whenever possible; the best remaining recipient vessel was randomized to radial artery vs saphenous vein graft. Main Outcome Measures: The primary end point was angiographic graft patency at 1 year after CABG. Secondary end points included angiographic graft patency at 1 week after CABG, myocardial infarction, stroke, repeat revascularization, and death. Results: Analysis included 733 patients (366 in the radial artery group, 367 in the saphenous vein group). There was no significant difference in study graft patency at 1 year after CABG (radial artery, 238/266; 89{\%}; 95{\%} confidence interval [CI], 86{\%}-93{\%}; saphenous vein, 239/269; 89{\%}; 95{\%} CI, 85{\%}-93{\%}; adjusted OR, 0.99; 95{\%} CI, 0.56-1.74; P=.98). There were no significant differences in the secondary end points. Conclusion: Among Veterans Affairs patients undergoing first-time elective CABG, the use of a radial artery graft compared with saphenous vein graft did not result in greater 1-year patency. Trial Registration: clinicaltrials.gov Identifier: NCT00054847",
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AU - Goldman, Steven

AU - Sethi, Gulshan K.

AU - Holman, William

AU - Thai, Hoang

AU - McFalls, Edward

AU - Ward, Herbert B.

AU - Kelly, Rosemary F.

AU - Rhenman, Birger

AU - Tobler, Gareth H.

AU - Bakaeen, Faisal G.

AU - Huh, Joseph

AU - Soltero, Ernesto

AU - Moursi, Mohammed

AU - Haime, Miguel

AU - Crittenden, Michael

AU - Kasirajan, Vigneshwar

AU - Ratliff, Michelle

AU - Pett, Stewart

AU - Irimpen, Anand

AU - Gunnar, William

AU - Thomas, Donald

AU - Fremes, Stephen

AU - Moritz, Thomas

AU - Reda, Domenic

AU - Harrison, Lynn

AU - Wagner, Todd H.

AU - Wang, Yajie

AU - Planting, Lori

AU - Miller, Meredith

AU - Rodriguez, Yvette

AU - Juneman, Elizabeth B

AU - Morrison, Douglass

AU - Pierce, Mary Kaye

AU - Kreamer, Sandra

AU - Shih, Mei Chiung

AU - Lee, Kelvin

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