Radiation Treatment Decreases Bone Cancer Pain, Osteolysis and Tumor Size

M. Goblirsch, W. Mathews, C. Lynch, P. Alaei, B. J. Gerbi, P. W. Mantyh, D. R. Clohisy

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Radiotherapy is the cornerstone of palliative treatment for primary bone cancer in animals and metastatic bone cancer in humans. However, the mechanism(s) responsible for pain relief after irradiation is unknown. To identify the mechanism through which radiation treatment decreases bone cancer pain, the effect of radiation on mice with painful bone cancer was studied. Analysis of the effects of a 20-Gy treatment on localized sites of painful bone cancers was performed through assessments of animal behavior, radiographs and histological analysis. The findings indicated that radiation treatment reduced bone pain and supported reduced cancer burden and reduced osteolysis as mechanisms through which radiation reduces bone cancer pain.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalRadiation Research
Volume161
Issue number2
DOIs
StatePublished - Feb 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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