Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

Vahe Bandarian, Catherine L. Drennan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.

Original languageEnglish (US)
Pages (from-to)116-124
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume35
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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