Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Anthony P. Young, Vahe Bandarian

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNAPhe in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.

Original languageEnglish (US)
Pages (from-to)613-618
Number of pages6
JournalCurrent Opinion in Chemical Biology
Volume17
Issue number4
DOIs
StatePublished - Aug 2013

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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