Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Anthony P. Young, Vahe Bandarian

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNAPhe in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.

Original languageEnglish (US)
Pages (from-to)613-618
Number of pages6
JournalCurrent Opinion in Chemical Biology
Volume17
Issue number4
DOIs
StatePublished - Aug 2013

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RNA, Transfer, Phe
Biosynthesis
Archaea
Transfer RNA
Eukaryota
Pyruvic Acid
Condensation
Derivatives
Acids
wyosine
4-demethylwyosine
1-methylguanosine
wybutosine

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry

Cite this

Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine. / Young, Anthony P.; Bandarian, Vahe.

In: Current Opinion in Chemical Biology, Vol. 17, No. 4, 08.2013, p. 613-618.

Research output: Contribution to journalArticle

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