Radiosensitive, thymic hormone-sensitive peripheral blood suppressor cell activity in cancer patients

Evan M Hersh, Y. Z. Patt, S. G. Murphy, K. Dicke, A. Zander, M. Adegbite, R. Goldman

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Suppressor cell activity which was radiosensitive in most subjects and thymic hormone sensitive in some was identified in patients with cancer, and compared to simultaneously studied normal controls. Suppressor cell activity was measured in cocultures of normal lymphocytes with patient lymphocytes added in microwells using the blastogenic response to phytohemagglutinin and concanavalin A as the measure of activity. Thirty-five patients (lung cancer, 21; leukemia in remission, seven; and various solid tumors, seven) and an equal number of controls were studied. Suppressor cell activity was identified in 71% of the patients. In approximately 75% of these, the suppressor cell activity was radiosensitive (4000 to 6000 rads). For the phytohemagglutinin response, suppressor activity was thymic hormone sensitive in approximately 40% (Thymosin Fraction 5 or thymic humoral factor), and for the concanavalin A response, it was thymic hormone sensitive in about 25% of the cases. There was a significant correlation between the presence of immunodeficiency (defined as a phytohemagglutinin response <35,000 or a concanavalin A response <12,000 cpm) and the presence of the suppressor cell activity. The suppressor cell activity was heterogenous relative to its radiosensitivity and thymic hormone sensitivity. Suppressor cell activity was observed in all the patient categories. These results indicate that certain available therapeutic manipulations may have significant effects on suppressor cell activity and should be an important subject for further investigation.

Original languageEnglish (US)
Pages (from-to)3134-3140
Number of pages7
JournalCancer Research
Volume40
Issue number9
StatePublished - 1980
Externally publishedYes

Fingerprint

Thymus Hormones
Blood Cells
Neoplasms
Phytohemagglutinins
Concanavalin A
Lymphocytes
Radiation Tolerance
Coculture Techniques
Lung Neoplasms
Leukemia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hersh, E. M., Patt, Y. Z., Murphy, S. G., Dicke, K., Zander, A., Adegbite, M., & Goldman, R. (1980). Radiosensitive, thymic hormone-sensitive peripheral blood suppressor cell activity in cancer patients. Cancer Research, 40(9), 3134-3140.

Radiosensitive, thymic hormone-sensitive peripheral blood suppressor cell activity in cancer patients. / Hersh, Evan M; Patt, Y. Z.; Murphy, S. G.; Dicke, K.; Zander, A.; Adegbite, M.; Goldman, R.

In: Cancer Research, Vol. 40, No. 9, 1980, p. 3134-3140.

Research output: Contribution to journalArticle

Hersh, EM, Patt, YZ, Murphy, SG, Dicke, K, Zander, A, Adegbite, M & Goldman, R 1980, 'Radiosensitive, thymic hormone-sensitive peripheral blood suppressor cell activity in cancer patients', Cancer Research, vol. 40, no. 9, pp. 3134-3140.
Hersh EM, Patt YZ, Murphy SG, Dicke K, Zander A, Adegbite M et al. Radiosensitive, thymic hormone-sensitive peripheral blood suppressor cell activity in cancer patients. Cancer Research. 1980;40(9):3134-3140.
Hersh, Evan M ; Patt, Y. Z. ; Murphy, S. G. ; Dicke, K. ; Zander, A. ; Adegbite, M. ; Goldman, R. / Radiosensitive, thymic hormone-sensitive peripheral blood suppressor cell activity in cancer patients. In: Cancer Research. 1980 ; Vol. 40, No. 9. pp. 3134-3140.
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