Abstract
In a randomized open crossover study, the antiemetic efficacy of a five-drug antiemetic regimen consisting of metoclopramide, dexamethasone, diazepam, diphenhydramine, and thiethylperazine was compared to that of high-dose metoclopramide. Thirteen patients treated with cisplatin combination chemotherapy regimens were evaluated. The study was terminated prior to accrual of the planned number of patients because of the statistically significant difference in efficacy between treatments found at interim analysis. The duration of nausea and number of vomiting episodes on the day of chemotherapy were significantly less (p < 0.01) after receiving the five-drug combination. After receiving the five-drug regimen, 77% of the patients did not experience any episodes of vomiting on day 1, and 8% of patients had only one episode. In contrast, only 31% of patients treated with high-dose metoclopramide did not have any episodes of vomiting on day 1, and 61% of the patients had five or more episodes. None of the patients treated with the five-drug regimen required additional antiemetic administration. Although both regimens were, in general, well tolerated, when given the choice of continuing antiemetic therapies, 92% of the patients preferred the five-drug antiemetic combination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 101-108 |
| Number of pages | 8 |
| Journal | Journal of Nurse-Midwifery |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1990 |
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Keywords
- Antiemetic combinations
- cisplatin
ASJC Scopus subject areas
- Nursing(all)
Cite this
Randomized crossover comparison of high-dose intravenous metoclopramide versus a five-drug antiemetic regimen. / Plezia, Patricia M.; Alberts, David S; Kessler, John F.; Berens, Patricia L.; Chase, Judy L.; Roe, Denise.
In: Journal of Nurse-Midwifery, Vol. 5, No. 2, 01.01.1990, p. 101-108.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Randomized crossover comparison of high-dose intravenous metoclopramide versus a five-drug antiemetic regimen
AU - Plezia, Patricia M.
AU - Alberts, David S
AU - Kessler, John F.
AU - Berens, Patricia L.
AU - Chase, Judy L.
AU - Roe, Denise
PY - 1990/1/1
Y1 - 1990/1/1
N2 - In a randomized open crossover study, the antiemetic efficacy of a five-drug antiemetic regimen consisting of metoclopramide, dexamethasone, diazepam, diphenhydramine, and thiethylperazine was compared to that of high-dose metoclopramide. Thirteen patients treated with cisplatin combination chemotherapy regimens were evaluated. The study was terminated prior to accrual of the planned number of patients because of the statistically significant difference in efficacy between treatments found at interim analysis. The duration of nausea and number of vomiting episodes on the day of chemotherapy were significantly less (p < 0.01) after receiving the five-drug combination. After receiving the five-drug regimen, 77% of the patients did not experience any episodes of vomiting on day 1, and 8% of patients had only one episode. In contrast, only 31% of patients treated with high-dose metoclopramide did not have any episodes of vomiting on day 1, and 61% of the patients had five or more episodes. None of the patients treated with the five-drug regimen required additional antiemetic administration. Although both regimens were, in general, well tolerated, when given the choice of continuing antiemetic therapies, 92% of the patients preferred the five-drug antiemetic combination.
AB - In a randomized open crossover study, the antiemetic efficacy of a five-drug antiemetic regimen consisting of metoclopramide, dexamethasone, diazepam, diphenhydramine, and thiethylperazine was compared to that of high-dose metoclopramide. Thirteen patients treated with cisplatin combination chemotherapy regimens were evaluated. The study was terminated prior to accrual of the planned number of patients because of the statistically significant difference in efficacy between treatments found at interim analysis. The duration of nausea and number of vomiting episodes on the day of chemotherapy were significantly less (p < 0.01) after receiving the five-drug combination. After receiving the five-drug regimen, 77% of the patients did not experience any episodes of vomiting on day 1, and 8% of patients had only one episode. In contrast, only 31% of patients treated with high-dose metoclopramide did not have any episodes of vomiting on day 1, and 61% of the patients had five or more episodes. None of the patients treated with the five-drug regimen required additional antiemetic administration. Although both regimens were, in general, well tolerated, when given the choice of continuing antiemetic therapies, 92% of the patients preferred the five-drug antiemetic combination.
KW - Antiemetic combinations
KW - cisplatin
UR - http://www.scopus.com/inward/record.url?scp=85049057184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049057184&partnerID=8YFLogxK
U2 - 10.1016/0091-2182(90)90007-R
DO - 10.1016/0091-2182(90)90007-R
M3 - Article
VL - 5
SP - 101
EP - 108
JO - Journal of Midwifery and Women's Health
JF - Journal of Midwifery and Women's Health
SN - 1526-9523
IS - 2
ER -