Randomized phase III trial of chemoimmunotherapy in patients with previously untreated stage III, optimal disease ovarian cancer: A Southwest Oncology Group study

David S. Alberts, Nancy Mason-Liddil, Robert V. O'Toole, Thomas M. Abbott, Richard Kronmal, Robert D. Hilgers, Earl A. Surwit, Harmon J. Eyre, Laurence H. Baker

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Between 1979 and 1984, 98 patients considered to have stage III epithelial type ovarian cancer and optimal surgical resections (i.e., < 2 cm residual tumor masses) were randomly assigned to treatment with doxorubicin + cyclophosphamide + BCG (DC + BCG) vs doxorubicin + cyclophosphamide + cisplatin (DCP) vs. doxorubicin + cyclophosphamide + cisplatin + BCG (DCP + BCG). Seventeen (17%) were considered ineligible on the basis of formal histopathologic review. The pathologically proven complete response rates for DC + BCG, DCP, and DCP + BCG-treated patients were 20, 23, and 41%, respectively, and the median survival durations were 36.8, 48.2, and 57.4 months, respectively. Because of the relatively small sample size, definite conclusions concerning the response or survival impact of adding cisplatin to DC + BCG or BCG to DCP can not be drawn; nevertheless, all three groups of patients experienced prolonged survival durations with approximately 40% of all eligible patients alive at 5 years.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalGynecologic oncology
Volume32
Issue number1
DOIs
StatePublished - Jan 1989

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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