Rapid assembly of matrix metalloprotease inhibitors using click chemistry

Jun Wang, Mahesh Uttamchandani, Junqi Li, Mingyu Hu, Shao Q. Yao

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A panel of 96 metalloprotease inhibitors was assembled using "click chemistry" by reacting eight zinc-binding hydroxamate warheads with 12 azide building blocks. Screens of the bidentate compounds against representative metalloproteases provided discerning inhibition fingerprints, revealing compounds with low micromolar potency against MMP-7. The relative ease and convenience of the strategy in constructing focused chemical libraries for rapid in situ screening of MMPs is thereby demonstrated.

Original languageEnglish (US)
Pages (from-to)3821-3824
Number of pages4
JournalOrganic Letters
Volume8
Issue number17
DOIs
StatePublished - Aug 17 2006
Externally publishedYes

Fingerprint

warheads
Click Chemistry
Metalloproteases
Matrix Metalloproteinases
inhibitors
screening
assembly
zinc
chemistry
Small Molecule Libraries
Azides
Dermatoglyphics
matrices
Zinc
Screening

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Rapid assembly of matrix metalloprotease inhibitors using click chemistry. / Wang, Jun; Uttamchandani, Mahesh; Li, Junqi; Hu, Mingyu; Yao, Shao Q.

In: Organic Letters, Vol. 8, No. 17, 17.08.2006, p. 3821-3824.

Research output: Contribution to journalArticle

Wang, J, Uttamchandani, M, Li, J, Hu, M & Yao, SQ 2006, 'Rapid assembly of matrix metalloprotease inhibitors using click chemistry', Organic Letters, vol. 8, no. 17, pp. 3821-3824. https://doi.org/10.1021/ol061431a
Wang, Jun ; Uttamchandani, Mahesh ; Li, Junqi ; Hu, Mingyu ; Yao, Shao Q. / Rapid assembly of matrix metalloprotease inhibitors using click chemistry. In: Organic Letters. 2006 ; Vol. 8, No. 17. pp. 3821-3824.
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