Rapid DNA human identification system

Optimization of microfluidic integration

Matthew D. Estes, Cedric Hurth, Jianing Yang, Carla Brooks, Alan Nordquist, Stan Smith, Ralf Lenigk, Nina Moran, Andrew J. Hopwood, Gillian Tully, Frederic Zenhausern

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Within the law enforcement community, forensic lab work for genetic identification requires approximately two weeks, while the holding time for potential suspects is capped at 36 hours. There exists a dire need for the ability to process samples within this narrow window to prevent the inadvertent release of guilty parties. The lab-on-a-chip cartridge and instrumentation presented within this paper, illustrated in Figure 1, are capable of processing time sensitive samples from deoxyribonucleic acid (DNA) purification to detection in under 2 hours, automating every step of the process while also improving reliability and reducing reagent cost and risk of contamination.

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages2102-2104
Number of pages3
Volume3
StatePublished - 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

Fingerprint

Lab-on-a-chip
Law enforcement
Microfluidics
Purification
Identification (control systems)
Contamination
DNA
Processing
Costs

Keywords

  • Forensic
  • HID
  • SP-PCR-CE
  • STR

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Estes, M. D., Hurth, C., Yang, J., Brooks, C., Nordquist, A., Smith, S., ... Zenhausern, F. (2011). Rapid DNA human identification system: Optimization of microfluidic integration. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (Vol. 3, pp. 2102-2104)

Rapid DNA human identification system : Optimization of microfluidic integration. / Estes, Matthew D.; Hurth, Cedric; Yang, Jianing; Brooks, Carla; Nordquist, Alan; Smith, Stan; Lenigk, Ralf; Moran, Nina; Hopwood, Andrew J.; Tully, Gillian; Zenhausern, Frederic.

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 3 2011. p. 2102-2104.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Estes, MD, Hurth, C, Yang, J, Brooks, C, Nordquist, A, Smith, S, Lenigk, R, Moran, N, Hopwood, AJ, Tully, G & Zenhausern, F 2011, Rapid DNA human identification system: Optimization of microfluidic integration. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. vol. 3, pp. 2102-2104, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States, 10/2/11.
Estes MD, Hurth C, Yang J, Brooks C, Nordquist A, Smith S et al. Rapid DNA human identification system: Optimization of microfluidic integration. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 3. 2011. p. 2102-2104
Estes, Matthew D. ; Hurth, Cedric ; Yang, Jianing ; Brooks, Carla ; Nordquist, Alan ; Smith, Stan ; Lenigk, Ralf ; Moran, Nina ; Hopwood, Andrew J. ; Tully, Gillian ; Zenhausern, Frederic. / Rapid DNA human identification system : Optimization of microfluidic integration. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 3 2011. pp. 2102-2104
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