Rapid elevation of rat serum prolactin concentration by cyclosporine, a novel immunosuppressive drug

Stephan B. Cardon, Douglas F Larson, Diane Haddock Russell

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Within one hr of the administration of cyclosporine to rats, there was a 4-fold elevation in the serum prolactin concentration. Doses of 0.12, 1.2, and 12 μg/100 g body weight cyclosporine significantly elevated the serum prolactin level. Higher doses, 120 or 1200 μg/100 g body weight cyclosporine resulted in small but insignificant elevations of the serum prolactin concentration. Bromocriptine, a dopamine agonist which inhibits prolactin release from the anterior pituitary, completely blocked the elevation in serum prolactin in response to cyclosporine alone. These data suggest that the ability of cyclosporine to suppress immune function may involve its ability to rapidly produce hyperprolactinemia.

Original languageEnglish (US)
Pages (from-to)614-618
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume120
Issue number2
DOIs
Publication statusPublished - Apr 30 1984

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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