Rapid molecular diagnosis of infective endocarditis: Developing μREx Dx

Dustin K. Harshman, Roberto Reyes, Jeong-Yeol Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We have developed a microfluidic device for rapid explicit diagnosis (μREx Dx) to address the presently unmet need for speedy, accurate diagnosis of cardiovascular infections. In order to decrease morbidity and mortality for patients with infective endocarditis (IE), μREx Dx rapidly provides clinically useful diagnostic information to facilitate the early use of appropriate therapy. Specifically, the total bacterial load of the sample is determined by 16s rDNA amplification, with the option for off-device sequencing, and the presence of plasmid-mediated antibiotic resistance gene, vanA, is detected. This system can have a major impact on molecular diagnosis of cardiovascular infection.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1051-1053
Number of pages3
ISBN (Print)9780979806476
StatePublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Keywords

  • Droplet microfluidics
  • Real-time polymerase chain reaction
  • Smartphone

ASJC Scopus subject areas

  • Control and Systems Engineering

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    Harshman, D. K., Reyes, R., & Yoon, J-Y. (2014). Rapid molecular diagnosis of infective endocarditis: Developing μREx Dx. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 1051-1053). Chemical and Biological Microsystems Society.