Rapid, shallow breathing after Ascaris suum antigen inhalation: role of vagus nerves

D. J. Cotton, E. R. Bleecker, S. P. Fischer, P. D. Graf, W. M. Gold, J. A. Nadel

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

In 5 treadmill-exercising, unsedated dogs, we studied the effect of inhaled Ascaris suum antigen aerosols on minute volume of ventilation (VE), respiratory frequency (f), tidal volume (VT), total pulmonary resistance (RL), and dynamic pulmonary compliance (CL(dyn)), before and during cooling of the vagus nerves. With the vagi warm, inhaled antigen increased VE (mean + 62%; P < 0.01) by increasing f (mean + 180%; P<0.01), despite a decrease in VT (mean - 42%; P<0.01). RL increased (mean + 170%; P < 0.001) and CL(dyn) decreased (mean - 43%; P< 0.005). With the vagi cool, inhaled antigen no longer affected VE, f, or VT (P > 0.5), although RL still increased and CL(dyn) still decreased. Inhalation of a bronchodilator, terbutaline, prevented the broncho-constriction induced by antigen but did not prevent the ventilatory response. We conclude that vagal afferent pathways mediate the ventilatory response to inhaled antigen and suggest that the primary stimulus for this response is not airway narrowing.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalUnknown Journal
Volume42
Issue number1
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

Fingerprint

Dive into the research topics of 'Rapid, shallow breathing after Ascaris suum antigen inhalation: role of vagus nerves'. Together they form a unique fingerprint.

Cite this