Rare transformation to double hit lymphoma in Waldenstrom's macroglobulinemia

Onyemaechi N. Okolo, Ariel C. Johnson, Seongseok Yun, Stacy J. Arnold, Faiz - Anwer

Research output: Contribution to journalArticle

Abstract

Waldenström macroglobulinemia (WM) is a lymphoproliferative lymphoma that is characterized by monoclonal immunoglobulin M (IgM) protein and bone marrow infiltration. Its incidence is rare and rarer still is its ability to transform to a B-cell lymphoma, particularly the aggressive diffuse large B-cell lymphoma, which bodes a poor prognosis. When transformation includes mutations of MYC, BCL-2 and/or BCL-6, it is known as a 'double hit' or 'triple hit' lymphoma respectively. This paper presents a rare case of WM with mutations positive for MYC and BCL2, making it a case of double hit B-cell lymphoplasmacytic lymphoma with plasmatic differentiation without morphological transformation to aggressive histology like DLBCL. The paper also broadens to include discussions on current topics in the classification, diagnosis, possible causes of transformation, and treatment of WM, including transformation to double hit lymphoma. The significance of this case lies in that the presence of double hit lymphoma-like genetic mutations in WM have not been previously described in the literature and potentially such changes are harbinger of extra-nodal presentation, aggressive growth, and possibly poor prognosis, if data from other double-hit lymphoma are extrapolated.

Original languageEnglish (US)
Pages (from-to)709-714
Number of pages6
JournalImmunotherapy
Volume9
Issue number9
DOIs
StatePublished - Aug 1 2017

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Waldenstrom Macroglobulinemia
Lymphoma
B-Cell Lymphoma
Mutation
Lymphoma, Large B-Cell, Diffuse
Immunoglobulin M
Histology
Bone Marrow
Incidence
Growth
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

Cite this

Rare transformation to double hit lymphoma in Waldenstrom's macroglobulinemia. / Okolo, Onyemaechi N.; Johnson, Ariel C.; Yun, Seongseok; Arnold, Stacy J.; Anwer, Faiz -.

In: Immunotherapy, Vol. 9, No. 9, 01.08.2017, p. 709-714.

Research output: Contribution to journalArticle

Okolo, Onyemaechi N. ; Johnson, Ariel C. ; Yun, Seongseok ; Arnold, Stacy J. ; Anwer, Faiz -. / Rare transformation to double hit lymphoma in Waldenstrom's macroglobulinemia. In: Immunotherapy. 2017 ; Vol. 9, No. 9. pp. 709-714.
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