Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase: A model for enzymatic catalysis

Joshua S. Mincer; Steven D. Schwartz

doi:10.1063/1.1690239

Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase: A model for enzymatic catalysis

Joshua S. Mincer, Steven D. Schwartz

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

A model is proposed for coupled hydrogen-electron transfer reactions in condensed phase in the presence of a promoting vibration. The model is an extension of an earlier model, which modulates the potential the hydrogen atom experiences as it is transferred. Large kinetic isotope effects (KIE) were found when the hydrogen is substituted with deutrium. The results show that a large, temperature-independent KIE is compatible with a tunneling reaction assisted by a promoting vibration.

Original language	English (US)
Pages (from-to)	7755-7760
Number of pages	6
Journal	Journal of Chemical Physics
Volume	120
Issue number	16
DOIs	https://doi.org/10.1063/1.1690239
State	Published - Apr 22 2004
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy(all)
Physical and Theoretical Chemistry

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10.1063/1.1690239

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abstract = "A model is proposed for coupled hydrogen-electron transfer reactions in condensed phase in the presence of a promoting vibration. The model is an extension of an earlier model, which modulates the potential the hydrogen atom experiences as it is transferred. Large kinetic isotope effects (KIE) were found when the hydrogen is substituted with deutrium. The results show that a large, temperature-independent KIE is compatible with a tunneling reaction assisted by a promoting vibration.",

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Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase: A model for enzymatic catalysis

Abstract

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