Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase: A model for enzymatic catalysis

Joshua S. Mincer; Steven D. Schwartz

doi:10.1063/1.1690239

Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase: A model for enzymatic catalysis

Joshua S. Mincer, Steven D. Schwartz

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

A model is proposed for coupled hydrogen-electron transfer reactions in condensed phase in the presence of a promoting vibration. The model is an extension of an earlier model, which modulates the potential the hydrogen atom experiences as it is transferred. Large kinetic isotope effects (KIE) were found when the hydrogen is substituted with deutrium. The results show that a large, temperature-independent KIE is compatible with a tunneling reaction assisted by a promoting vibration.

Original language	English (US)
Pages (from-to)	7755-7760
Number of pages	6
Journal	Journal of Chemical Physics
Volume	120
Issue number	16
DOIs	https://doi.org/10.1063/1.1690239
State	Published - Apr 22 2004
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy(all)
Physical and Theoretical Chemistry

Access to Document

10.1063/1.1690239

Fingerprint Dive into the research topics of 'Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase: A model for enzymatic catalysis'. Together they form a unique fingerprint.

Cite this

@article{67fd97879e344c2fb9726cb78b1351f5,

title = "Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase: A model for enzymatic catalysis",

abstract = "A model is proposed for coupled hydrogen-electron transfer reactions in condensed phase in the presence of a promoting vibration. The model is an extension of an earlier model, which modulates the potential the hydrogen atom experiences as it is transferred. Large kinetic isotope effects (KIE) were found when the hydrogen is substituted with deutrium. The results show that a large, temperature-independent KIE is compatible with a tunneling reaction assisted by a promoting vibration.",

author = "Mincer, {Joshua S.} and Schwartz, {Steven D.}",

year = "2004",

month = apr,

day = "22",

doi = "10.1063/1.1690239",

language = "English (US)",

volume = "120",

pages = "7755--7760",

journal = "Journal of Chemical Physics",

issn = "0021-9606",

publisher = "American Institute of Physics Publising LLC",

number = "16",

}

TY - JOUR

T1 - Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase

T2 - A model for enzymatic catalysis

AU - Mincer, Joshua S.

AU - Schwartz, Steven D.

PY - 2004/4/22

Y1 - 2004/4/22

N2 - A model is proposed for coupled hydrogen-electron transfer reactions in condensed phase in the presence of a promoting vibration. The model is an extension of an earlier model, which modulates the potential the hydrogen atom experiences as it is transferred. Large kinetic isotope effects (KIE) were found when the hydrogen is substituted with deutrium. The results show that a large, temperature-independent KIE is compatible with a tunneling reaction assisted by a promoting vibration.

AB - A model is proposed for coupled hydrogen-electron transfer reactions in condensed phase in the presence of a promoting vibration. The model is an extension of an earlier model, which modulates the potential the hydrogen atom experiences as it is transferred. Large kinetic isotope effects (KIE) were found when the hydrogen is substituted with deutrium. The results show that a large, temperature-independent KIE is compatible with a tunneling reaction assisted by a promoting vibration.

UR - http://www.scopus.com/inward/record.url?scp=2342448523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342448523&partnerID=8YFLogxK

U2 - 10.1063/1.1690239

DO - 10.1063/1.1690239

M3 - Article

C2 - 15267689

AN - SCOPUS:2342448523

VL - 120

SP - 7755

EP - 7760

JO - Journal of Chemical Physics

JF - Journal of Chemical Physics

SN - 0021-9606

IS - 16

ER -

Rate-promoting vibrations and coupled hydrogen-electron transfer reactions in the condensed phase: A model for enzymatic catalysis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this