Rationale for design of biologically reversible drug derivatives: Prodrugs

A. A. Sinkula, S. H. Yalkowsky

Research output: Contribution to journalReview articlepeer-review

219 Scopus citations
Original languageEnglish (US)
Pages (from-to)181-210
Number of pages30
JournalJournal of pharmaceutical sciences
Volume64
Issue number2
DOIs
StatePublished - Feb 1975
Externally publishedYes

Keywords

  • Chemical modification—prodrugs, physicochemical and biological considerations, applications, review
  • Drug derivatives, biologically reversible—rationale for design of prodrugs, physicochemical and biological considerations, applications, review
  • Latentiated drugs—design of prodrugs, review
  • Prodrugs—rationale for design, physicochemical and biological considerations, applications, modifications affecting absorption, site direction, depot, taste and odor, and irritation, review
  • Reversible drug derivatives—rationale for design for prodrugs, physicochemical and biological considerations, applications, review

ASJC Scopus subject areas

  • Pharmaceutical Science

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