Rationale for using pathologic tumor dimensions and nodal status to subclassify surgically treated stage IB cervical cancer patients

Ronald D. Alvarez, Mark E. Potter, Seng Jaw Soong, Frank L. Gay, Kenneth D. Hatch, Edward E. Partridge, Hugh M. Shingleton

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Between 1969 and 1988, 401 patients were treated by radical hysterectomy and pelvic lymphadenectomy for Stage IB cervical carcinoma at the University of Alabama at Birmingham. In multivariate analysis, pathological tumor diameter (P < 0.0001) and the presence of lymph node metastasis (P = 0.0005) proved to be the dominant two histopathologic features that significantly correlated with overall survival. Although 5-year survival for the overall group was 85%, 5-year survival in patients with lesions >3.0 cm in diameter and with regional nodal metastasis was less than 30%. This discrepancy in survival in surgically treated early-stage cervical cancer patients supports a need for subcategorization by risk factors such as pathologic tumor dimensions and nodal status and for further investigation of alternative neoadjuvant and adjuvant therapies in those early-stage cervical cancer patients deemed at high risk for poor overall survival.

Original languageEnglish (US)
Pages (from-to)108-112
Number of pages5
JournalGynecologic oncology
Volume43
Issue number2
DOIs
StatePublished - Nov 1991
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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