Rationale for using pathologic tumor dimensions and nodal status to subclassify surgically treated stage IB cervical cancer patients

Ronald D. Alvarez, Mark E. Potter, Seng Jaw Soong, Frank L. Gay, Kenneth D Hatch, Edward E. Partridge, Hugh M. Shingleton

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Between 1969 and 1988, 401 patients were treated by radical hysterectomy and pelvic lymphadenectomy for Stage IB cervical carcinoma at the University of Alabama at Birmingham. In multivariate analysis, pathological tumor diameter (P < 0.0001) and the presence of lymph node metastasis (P = 0.0005) proved to be the dominant two histopathologic features that significantly correlated with overall survival. Although 5-year survival for the overall group was 85%, 5-year survival in patients with lesions >3.0 cm in diameter and with regional nodal metastasis was less than 30%. This discrepancy in survival in surgically treated early-stage cervical cancer patients supports a need for subcategorization by risk factors such as pathologic tumor dimensions and nodal status and for further investigation of alternative neoadjuvant and adjuvant therapies in those early-stage cervical cancer patients deemed at high risk for poor overall survival.

Original languageEnglish (US)
Pages (from-to)108-112
Number of pages5
JournalGynecologic Oncology
Volume43
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Uterine Cervical Neoplasms
Neoplasms
Neoadjuvant Therapy
Survival
Complementary Therapies
Lymph Node Excision
Hysterectomy
Multivariate Analysis
Neoplasm Metastasis
Carcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Rationale for using pathologic tumor dimensions and nodal status to subclassify surgically treated stage IB cervical cancer patients. / Alvarez, Ronald D.; Potter, Mark E.; Soong, Seng Jaw; Gay, Frank L.; Hatch, Kenneth D; Partridge, Edward E.; Shingleton, Hugh M.

In: Gynecologic Oncology, Vol. 43, No. 2, 1991, p. 108-112.

Research output: Contribution to journalArticle

Alvarez, Ronald D. ; Potter, Mark E. ; Soong, Seng Jaw ; Gay, Frank L. ; Hatch, Kenneth D ; Partridge, Edward E. ; Shingleton, Hugh M. / Rationale for using pathologic tumor dimensions and nodal status to subclassify surgically treated stage IB cervical cancer patients. In: Gynecologic Oncology. 1991 ; Vol. 43, No. 2. pp. 108-112.
@article{8ad6cdb30bb64d6485c7534683d6a1be,
title = "Rationale for using pathologic tumor dimensions and nodal status to subclassify surgically treated stage IB cervical cancer patients",
abstract = "Between 1969 and 1988, 401 patients were treated by radical hysterectomy and pelvic lymphadenectomy for Stage IB cervical carcinoma at the University of Alabama at Birmingham. In multivariate analysis, pathological tumor diameter (P < 0.0001) and the presence of lymph node metastasis (P = 0.0005) proved to be the dominant two histopathologic features that significantly correlated with overall survival. Although 5-year survival for the overall group was 85{\%}, 5-year survival in patients with lesions >3.0 cm in diameter and with regional nodal metastasis was less than 30{\%}. This discrepancy in survival in surgically treated early-stage cervical cancer patients supports a need for subcategorization by risk factors such as pathologic tumor dimensions and nodal status and for further investigation of alternative neoadjuvant and adjuvant therapies in those early-stage cervical cancer patients deemed at high risk for poor overall survival.",
author = "Alvarez, {Ronald D.} and Potter, {Mark E.} and Soong, {Seng Jaw} and Gay, {Frank L.} and Hatch, {Kenneth D} and Partridge, {Edward E.} and Shingleton, {Hugh M.}",
year = "1991",
doi = "10.1016/0090-8258(91)90054-9",
language = "English (US)",
volume = "43",
pages = "108--112",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Rationale for using pathologic tumor dimensions and nodal status to subclassify surgically treated stage IB cervical cancer patients

AU - Alvarez, Ronald D.

AU - Potter, Mark E.

AU - Soong, Seng Jaw

AU - Gay, Frank L.

AU - Hatch, Kenneth D

AU - Partridge, Edward E.

AU - Shingleton, Hugh M.

PY - 1991

Y1 - 1991

N2 - Between 1969 and 1988, 401 patients were treated by radical hysterectomy and pelvic lymphadenectomy for Stage IB cervical carcinoma at the University of Alabama at Birmingham. In multivariate analysis, pathological tumor diameter (P < 0.0001) and the presence of lymph node metastasis (P = 0.0005) proved to be the dominant two histopathologic features that significantly correlated with overall survival. Although 5-year survival for the overall group was 85%, 5-year survival in patients with lesions >3.0 cm in diameter and with regional nodal metastasis was less than 30%. This discrepancy in survival in surgically treated early-stage cervical cancer patients supports a need for subcategorization by risk factors such as pathologic tumor dimensions and nodal status and for further investigation of alternative neoadjuvant and adjuvant therapies in those early-stage cervical cancer patients deemed at high risk for poor overall survival.

AB - Between 1969 and 1988, 401 patients were treated by radical hysterectomy and pelvic lymphadenectomy for Stage IB cervical carcinoma at the University of Alabama at Birmingham. In multivariate analysis, pathological tumor diameter (P < 0.0001) and the presence of lymph node metastasis (P = 0.0005) proved to be the dominant two histopathologic features that significantly correlated with overall survival. Although 5-year survival for the overall group was 85%, 5-year survival in patients with lesions >3.0 cm in diameter and with regional nodal metastasis was less than 30%. This discrepancy in survival in surgically treated early-stage cervical cancer patients supports a need for subcategorization by risk factors such as pathologic tumor dimensions and nodal status and for further investigation of alternative neoadjuvant and adjuvant therapies in those early-stage cervical cancer patients deemed at high risk for poor overall survival.

UR - http://www.scopus.com/inward/record.url?scp=0026331836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026331836&partnerID=8YFLogxK

U2 - 10.1016/0090-8258(91)90054-9

DO - 10.1016/0090-8258(91)90054-9

M3 - Article

C2 - 1743550

AN - SCOPUS:0026331836

VL - 43

SP - 108

EP - 112

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 2

ER -