Rationale of platelet gel to augment adaptive remodeling of the injured heart

Christopher Mogan, Douglas F Larson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cardiac pathologic events including; myocardial infarction, viral infection and hypertrophy, and aging, may trigger maladaptive remodeling of the myocardium. Maladaptive remodeling results in diastolic and systolic dysfunction, myocyte loss, and malformation of the extracellular matrix. It is proposed that platelet gel applied to the site of myocardial injury may provide the proper cytokines, growth factors, and chemokines to promote adaptive remodeling. The hypothesis is that platelet gel concentrates may provide a temporary and local hyperphysiologic concentration of platelet secretory factors that may initiate adaptive myocardial healing. Autologous platelet gel can be derived from concentrated platelets activated and induced to secrete cytokines, growth factors, and chemokines with an array of stimulating agents. This report discusses selected platelet secretory factors, including; IL-1β, TGF-β, TGF-α, FGF, EGF, PDGF, and IGF, which support the concept that platelet concentrates can mediate cardiac wound healing. In conclusion, application of platelet gel to areas of cardiac injury may offer a therapeutic means to stimulate myocyte regeneration, angiogenesis, and restoration of a normal extracellular matrix composition.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalJournal of Extra-Corporeal Technology
Volume36
Issue number2
StatePublished - Jun 2004

Fingerprint

Blood Platelets
Gels
Chemokines
Muscle Cells
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Cytokines
Wounds and Injuries
Virus Diseases
Interleukin-1
Epidermal Growth Factor
Wound Healing
Hypertrophy
Regeneration
Myocardium
Myocardial Infarction

Keywords

  • Fibroblasts
  • Growth factors
  • Remodeling

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Rationale of platelet gel to augment adaptive remodeling of the injured heart. / Mogan, Christopher; Larson, Douglas F.

In: Journal of Extra-Corporeal Technology, Vol. 36, No. 2, 06.2004, p. 191-196.

Research output: Contribution to journalArticle

@article{e3ae5228bcdb409eb26c032cefb2b161,
title = "Rationale of platelet gel to augment adaptive remodeling of the injured heart",
abstract = "Cardiac pathologic events including; myocardial infarction, viral infection and hypertrophy, and aging, may trigger maladaptive remodeling of the myocardium. Maladaptive remodeling results in diastolic and systolic dysfunction, myocyte loss, and malformation of the extracellular matrix. It is proposed that platelet gel applied to the site of myocardial injury may provide the proper cytokines, growth factors, and chemokines to promote adaptive remodeling. The hypothesis is that platelet gel concentrates may provide a temporary and local hyperphysiologic concentration of platelet secretory factors that may initiate adaptive myocardial healing. Autologous platelet gel can be derived from concentrated platelets activated and induced to secrete cytokines, growth factors, and chemokines with an array of stimulating agents. This report discusses selected platelet secretory factors, including; IL-1β, TGF-β, TGF-α, FGF, EGF, PDGF, and IGF, which support the concept that platelet concentrates can mediate cardiac wound healing. In conclusion, application of platelet gel to areas of cardiac injury may offer a therapeutic means to stimulate myocyte regeneration, angiogenesis, and restoration of a normal extracellular matrix composition.",
keywords = "Fibroblasts, Growth factors, Remodeling",
author = "Christopher Mogan and Larson, {Douglas F}",
year = "2004",
month = "6",
language = "English (US)",
volume = "36",
pages = "191--196",
journal = "Journal of Extra-Corporeal Technology",
issn = "0022-1058",
publisher = "American Society of Extra-Corporeal Technology",
number = "2",

}

TY - JOUR

T1 - Rationale of platelet gel to augment adaptive remodeling of the injured heart

AU - Mogan, Christopher

AU - Larson, Douglas F

PY - 2004/6

Y1 - 2004/6

N2 - Cardiac pathologic events including; myocardial infarction, viral infection and hypertrophy, and aging, may trigger maladaptive remodeling of the myocardium. Maladaptive remodeling results in diastolic and systolic dysfunction, myocyte loss, and malformation of the extracellular matrix. It is proposed that platelet gel applied to the site of myocardial injury may provide the proper cytokines, growth factors, and chemokines to promote adaptive remodeling. The hypothesis is that platelet gel concentrates may provide a temporary and local hyperphysiologic concentration of platelet secretory factors that may initiate adaptive myocardial healing. Autologous platelet gel can be derived from concentrated platelets activated and induced to secrete cytokines, growth factors, and chemokines with an array of stimulating agents. This report discusses selected platelet secretory factors, including; IL-1β, TGF-β, TGF-α, FGF, EGF, PDGF, and IGF, which support the concept that platelet concentrates can mediate cardiac wound healing. In conclusion, application of platelet gel to areas of cardiac injury may offer a therapeutic means to stimulate myocyte regeneration, angiogenesis, and restoration of a normal extracellular matrix composition.

AB - Cardiac pathologic events including; myocardial infarction, viral infection and hypertrophy, and aging, may trigger maladaptive remodeling of the myocardium. Maladaptive remodeling results in diastolic and systolic dysfunction, myocyte loss, and malformation of the extracellular matrix. It is proposed that platelet gel applied to the site of myocardial injury may provide the proper cytokines, growth factors, and chemokines to promote adaptive remodeling. The hypothesis is that platelet gel concentrates may provide a temporary and local hyperphysiologic concentration of platelet secretory factors that may initiate adaptive myocardial healing. Autologous platelet gel can be derived from concentrated platelets activated and induced to secrete cytokines, growth factors, and chemokines with an array of stimulating agents. This report discusses selected platelet secretory factors, including; IL-1β, TGF-β, TGF-α, FGF, EGF, PDGF, and IGF, which support the concept that platelet concentrates can mediate cardiac wound healing. In conclusion, application of platelet gel to areas of cardiac injury may offer a therapeutic means to stimulate myocyte regeneration, angiogenesis, and restoration of a normal extracellular matrix composition.

KW - Fibroblasts

KW - Growth factors

KW - Remodeling

UR - http://www.scopus.com/inward/record.url?scp=3142742302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142742302&partnerID=8YFLogxK

M3 - Article

C2 - 15334765

AN - SCOPUS:3142742302

VL - 36

SP - 191

EP - 196

JO - Journal of Extra-Corporeal Technology

JF - Journal of Extra-Corporeal Technology

SN - 0022-1058

IS - 2

ER -