RBC zinc protoporphyrin to screen blood donors for iron deficiency anemia

Ronald B Schifman, S. L. Rivers, P. R. Finley, C. Thies

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We evaluated a rapid RBC zinc protoporphyrin (ZP) test in 1,147 male and 615 female blood donors to study its value in screening for evolving iron deficiency anemia. Fifteen men (1.8%) and 32 women (7.9%) who returned to donate were found to be anemic. A matched sample analysis between anemic and nonanemic donors demonstrated significant differences in serum ferritin levels, percent iron saturation, and the RBC ZP level from samples collected during the initial evaluation. Red cell ZP correlated well with the natural logarithm of serum ferritin in both men and women who later became anemic. The predictive value of RBC ZP levels compared favorably with that of the serum ferritin level. We also observed a strong association between the yearly donation frequency and RBC ZP concentration. These findings indicate that predonation RBC ZP testing may be useful in screening for iron depletion and potential risk of anemia in blood donors.

Original languageEnglish (US)
Pages (from-to)2012-2015
Number of pages4
JournalJournal of the American Medical Association
Volume248
Issue number16
DOIs
StatePublished - 1982
Externally publishedYes

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Iron-Deficiency Anemias
Blood Donors
Ferritins
Iron
Serum
zinc protoporphyrin
Anemia
Tissue Donors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

RBC zinc protoporphyrin to screen blood donors for iron deficiency anemia. / Schifman, Ronald B; Rivers, S. L.; Finley, P. R.; Thies, C.

In: Journal of the American Medical Association, Vol. 248, No. 16, 1982, p. 2012-2015.

Research output: Contribution to journalArticle

Schifman, Ronald B ; Rivers, S. L. ; Finley, P. R. ; Thies, C. / RBC zinc protoporphyrin to screen blood donors for iron deficiency anemia. In: Journal of the American Medical Association. 1982 ; Vol. 248, No. 16. pp. 2012-2015.
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