Re-evaluation of glucagon1-6: The N-terminal hexapeptide of glucagon is not biologically active in the hepatic adenylate cyclase system

John T. Pelton, Dev Trivedi, Victor J. Hruby

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The N-terminal hexapeptide of glucagon and the corresponding carboxamide analog, were prepared by solid-phase synthesis and tested for biological activity in the hepatic adenylate cyclase system. Both peptides were found to be inactive, even at concentrations of 10 mM. The differences observed in the activity of our compounds compared to previous reports, is ascribed to the presence of a contaminant found in earlier preparations which activates adenylate cyclase.

Original languageEnglish (US)
Pages (from-to)1307-1314
Number of pages8
JournalLife Sciences
Volume33
Issue number13
DOIs
StatePublished - Sep 26 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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