Reactions of HNO with heme proteins: New routes to HNO-heme complexes and insight into physiological effects

Murugaeson R. Kumars, Jon M. Fukuto, Katrina M Miranda, Patrick J. Farmer

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The formation and interconversion of nitrogen oxides has been of interest in numerous contexts for decades. Early studies focused on gas-phase reactions, particularly with regard to industrial and atmospheric environments, and on nitrogen fixation. Additionally, investigation of the coordination chemistry of nitric oxide (NO) with hemoglobin dates back nearly a century. With the discovery in the early 1980s that NO is blosynthesized as a molecular signaling agent, the literature has been focused on the biological effects of nitrogen oxides, but the original concerns remain relevant. For instance, hemoglobin has long been known to react with nitrite, but this reductase activity has recently been considered to be important to produce NO under hypoxic conditions. The association of nitrosyl hydride (HNO; also commonly referred to as nitroxyl) with heme proteins can also produce NO by reductive nitrosylation. Furthermore, HNO is considered to be an intermediate in bacterial denitrification, but conclusive identification has been elusive. The authors of this article have approached the bioinorganic chemistry of HNO from different perspectives, which have converged because heme proteins are important biological targets of HNO.

Original languageEnglish (US)
Pages (from-to)6283-6292
Number of pages10
JournalInorganic Chemistry
Volume49
Issue number14
DOIs
StatePublished - Jul 19 2010

Fingerprint

physiological effects
Hemeproteins
nitric oxide
Heme
Nitric Oxide
routes
Nitrogen Oxides
proteins
nitrogen oxides
hemoglobin
Hemoglobins
Nitrite Reductases
Nitrogen fixation
chemistry
nitrogenation
biological effects
Denitrification
nitrites
hydrides
Gases

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Reactions of HNO with heme proteins : New routes to HNO-heme complexes and insight into physiological effects. / Kumars, Murugaeson R.; Fukuto, Jon M.; Miranda, Katrina M; Farmer, Patrick J.

In: Inorganic Chemistry, Vol. 49, No. 14, 19.07.2010, p. 6283-6292.

Research output: Contribution to journalArticle

Kumars, Murugaeson R. ; Fukuto, Jon M. ; Miranda, Katrina M ; Farmer, Patrick J. / Reactions of HNO with heme proteins : New routes to HNO-heme complexes and insight into physiological effects. In: Inorganic Chemistry. 2010 ; Vol. 49, No. 14. pp. 6283-6292.
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