Reactivation of hippocampal ensemble activity patterns in the aging rat

Jason L. Gerrard, Hemant Kudrimoti, Bruce L. McNaughton, Carol A Barnes

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In young rats, the pattern of neuronal ensemble activity correlations expressed among hippocampal pyramidal cells during behavior persists during subsequent quiet wakefulness and slow-wave sleep, a process that may facilitate the consolidation of episodic memories. The present study explored the hypothesis that age-related changes in this process might contribute to memory impairments observed during normal aging. Neuronal activity was recorded from CA1 pyramidal cells, and in both young and old rats, there was a strong similarity between the resting epoch activity patterns and those from the preceding behavior epoch. This similarity was strongest during sharp-wave events. There were no detectable differences in the reactivation process or the decay rate between the young and old age groups. Thus, age differences in spatial memory do not appear to be explainable by differences in the spontaneous reactivation of familiar patterns within the hippocampus during the immediate postbehavior period.

Original languageEnglish (US)
Pages (from-to)1180-1192
Number of pages13
JournalBehavioral Neuroscience
Volume115
Issue number6
DOIs
StatePublished - 2001

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Pyramidal Cells
Episodic Memory
Wakefulness
Hippocampus
Sleep
Age Groups
Spatial Memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Reactivation of hippocampal ensemble activity patterns in the aging rat. / Gerrard, Jason L.; Kudrimoti, Hemant; McNaughton, Bruce L.; Barnes, Carol A.

In: Behavioral Neuroscience, Vol. 115, No. 6, 2001, p. 1180-1192.

Research output: Contribution to journalArticle

Gerrard, Jason L. ; Kudrimoti, Hemant ; McNaughton, Bruce L. ; Barnes, Carol A. / Reactivation of hippocampal ensemble activity patterns in the aging rat. In: Behavioral Neuroscience. 2001 ; Vol. 115, No. 6. pp. 1180-1192.
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