Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber

Ragnar Olafsson, Daniel R. Bauer, Leonardo G. Montilla, Russell S. Witte

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

A clinical ultrasound scanner and 14 MHz linear array collected real-time photoacoustic images (PAI) during an injection of gold nanorods (GNRs) near the region of a mature PC-3 prostate tumor in mice implanted with a skin flap window chamber. Three dimensional spectroscopic PAI (690-900nm) was also performed to investigate absorption changes near the tumor and enhance specific detection of GNRs. Whereas GNRs improved PAI contrast ( + 18 dB), the photoacoustic spectrum was consistent with the elevated near infrared absorption of GNRs. The versatile imaging platform potentially accelerates development of photoacoustic contrast agents and drug delivery for cancer imaging and therapy.

Original languageEnglish (US)
Pages (from-to)18625-18632
Number of pages8
JournalOptics Express
Volume18
Issue number18
DOIs
StatePublished - Aug 30 2010

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ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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