Real-time in vivo color Doppler optical coherence tomography

Andrew M. Rollins, Siavash Yazdanfar, Jennifer K. Barton, Joseph A. Izatt

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissue-simulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of velocity measurement are discussed, as well as potential applications of real-time CDOCT.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalJournal of biomedical optics
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • Doppler flowmetry
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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