Reassessment of the principal characteristics of gastroesophageal reflux during the recumbent period using integrated actigraphy-acquired information

Choo Hean Poh, Anita Gasiorowska, Larissa Allen, Tomás Navarro-Rodriguez, Ibraheem Mizyed, Jeannette Powers, Bridget Moty, Stuart F Quan, Marcia R. Willis, Nicole Ashpole, Isaac Malagon, Ronnie Fass

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

OBJECTIVES: Characterization of gastroesophageal reflux (GERD) events during the sleep period has been hampered by lack of any patient-friendly technique that allows accurate assessment of sleep duration and awakening time, without confining patients to a sleep laboratory. Our aim was to compare principal reflux characteristics during the upright, recumbent-awake, and recumbent-asleep periods as well as to determine the effect of sleep awakenings on the principal reflux characteristics of the recumbent-asleep period using novel technology that allows integration of recorded actigraphy data into collected pH information.METHODS: Patients with heartburn at least three times a week for the previous 3 months were invited to participate in this study. All participants were evaluated by the demographics and the GERD Symptom Checklist questionnaires. Thereafter, patients underwent ambulatory 24-h esophageal pH monitoring concomitantly with actigraphy. A novel technique was used to superimpose simultaneously recorded raw actigraphy data over pH data, resulting in more accurate information about reflux events during upright, recumbent-awake, recumbent-asleep, and conscious awakening periods as well as the relationship between symptoms and acid reflux events in the aforementioned periods.RESULTS: Thirty-nine subjects (M/F: 26/13, mean age 56.614 years) with an abnormal pH test were enrolled into the study. The recumbent period appeared heterogeneous and was clearly divided into recumbent-awake (123.020.2 min) and recumbent-asleep (485.623.6 min) periods. The percent total time pH4, the mean number of acid reflux events, and the number of symptoms associated with reflux events were significantly greater in the recumbent-awake as compared with the recumbent-asleep period. The mean duration of an acid reflux event was not different among upright, recumbent-awake, and recumbent-asleep periods. However, short-duration reflux events during the sleep period were associated with conscious awakenings as compared with those during sleep (0.740.11 min vs. 1.640.3 min, P0.01).CONCLUSIONS: The recumbent period is divided into recumbent-awake and recumbent-asleep periods. The recumbent-awake period has significantly different principal reflux characteristics than the recumbent-asleep period. Duration of an acid reflux event during the recumbent-asleep period is not uniformly prolonged. Short-duration acid reflux events during the sleep period are likely due to conscious awakenings.

Original languageEnglish (US)
Pages (from-to)1024-1031
Number of pages8
JournalAmerican Journal of Gastroenterology
Volume105
Issue number5
DOIs
StatePublished - May 2010

Fingerprint

Actigraphy
Gastroesophageal Reflux
Sleep
Acids
Esophageal pH Monitoring
Heartburn
Checklist
Demography
Technology

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Reassessment of the principal characteristics of gastroesophageal reflux during the recumbent period using integrated actigraphy-acquired information. / Poh, Choo Hean; Gasiorowska, Anita; Allen, Larissa; Navarro-Rodriguez, Tomás; Mizyed, Ibraheem; Powers, Jeannette; Moty, Bridget; Quan, Stuart F; Willis, Marcia R.; Ashpole, Nicole; Malagon, Isaac; Fass, Ronnie.

In: American Journal of Gastroenterology, Vol. 105, No. 5, 05.2010, p. 1024-1031.

Research output: Contribution to journalArticle

Poh, CH, Gasiorowska, A, Allen, L, Navarro-Rodriguez, T, Mizyed, I, Powers, J, Moty, B, Quan, SF, Willis, MR, Ashpole, N, Malagon, I & Fass, R 2010, 'Reassessment of the principal characteristics of gastroesophageal reflux during the recumbent period using integrated actigraphy-acquired information', American Journal of Gastroenterology, vol. 105, no. 5, pp. 1024-1031. https://doi.org/10.1038/ajg.2009.636
Poh, Choo Hean ; Gasiorowska, Anita ; Allen, Larissa ; Navarro-Rodriguez, Tomás ; Mizyed, Ibraheem ; Powers, Jeannette ; Moty, Bridget ; Quan, Stuart F ; Willis, Marcia R. ; Ashpole, Nicole ; Malagon, Isaac ; Fass, Ronnie. / Reassessment of the principal characteristics of gastroesophageal reflux during the recumbent period using integrated actigraphy-acquired information. In: American Journal of Gastroenterology. 2010 ; Vol. 105, No. 5. pp. 1024-1031.
@article{ef822e69e6b2476caf9425a4c3de26cf,
title = "Reassessment of the principal characteristics of gastroesophageal reflux during the recumbent period using integrated actigraphy-acquired information",
abstract = "OBJECTIVES: Characterization of gastroesophageal reflux (GERD) events during the sleep period has been hampered by lack of any patient-friendly technique that allows accurate assessment of sleep duration and awakening time, without confining patients to a sleep laboratory. Our aim was to compare principal reflux characteristics during the upright, recumbent-awake, and recumbent-asleep periods as well as to determine the effect of sleep awakenings on the principal reflux characteristics of the recumbent-asleep period using novel technology that allows integration of recorded actigraphy data into collected pH information.METHODS: Patients with heartburn at least three times a week for the previous 3 months were invited to participate in this study. All participants were evaluated by the demographics and the GERD Symptom Checklist questionnaires. Thereafter, patients underwent ambulatory 24-h esophageal pH monitoring concomitantly with actigraphy. A novel technique was used to superimpose simultaneously recorded raw actigraphy data over pH data, resulting in more accurate information about reflux events during upright, recumbent-awake, recumbent-asleep, and conscious awakening periods as well as the relationship between symptoms and acid reflux events in the aforementioned periods.RESULTS: Thirty-nine subjects (M/F: 26/13, mean age 56.614 years) with an abnormal pH test were enrolled into the study. The recumbent period appeared heterogeneous and was clearly divided into recumbent-awake (123.020.2 min) and recumbent-asleep (485.623.6 min) periods. The percent total time pH4, the mean number of acid reflux events, and the number of symptoms associated with reflux events were significantly greater in the recumbent-awake as compared with the recumbent-asleep period. The mean duration of an acid reflux event was not different among upright, recumbent-awake, and recumbent-asleep periods. However, short-duration reflux events during the sleep period were associated with conscious awakenings as compared with those during sleep (0.740.11 min vs. 1.640.3 min, P0.01).CONCLUSIONS: The recumbent period is divided into recumbent-awake and recumbent-asleep periods. The recumbent-awake period has significantly different principal reflux characteristics than the recumbent-asleep period. Duration of an acid reflux event during the recumbent-asleep period is not uniformly prolonged. Short-duration acid reflux events during the sleep period are likely due to conscious awakenings.",
author = "Poh, {Choo Hean} and Anita Gasiorowska and Larissa Allen and Tom{\'a}s Navarro-Rodriguez and Ibraheem Mizyed and Jeannette Powers and Bridget Moty and Quan, {Stuart F} and Willis, {Marcia R.} and Nicole Ashpole and Isaac Malagon and Ronnie Fass",
year = "2010",
month = "5",
doi = "10.1038/ajg.2009.636",
language = "English (US)",
volume = "105",
pages = "1024--1031",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Reassessment of the principal characteristics of gastroesophageal reflux during the recumbent period using integrated actigraphy-acquired information

AU - Poh, Choo Hean

AU - Gasiorowska, Anita

AU - Allen, Larissa

AU - Navarro-Rodriguez, Tomás

AU - Mizyed, Ibraheem

AU - Powers, Jeannette

AU - Moty, Bridget

AU - Quan, Stuart F

AU - Willis, Marcia R.

AU - Ashpole, Nicole

AU - Malagon, Isaac

AU - Fass, Ronnie

PY - 2010/5

Y1 - 2010/5

N2 - OBJECTIVES: Characterization of gastroesophageal reflux (GERD) events during the sleep period has been hampered by lack of any patient-friendly technique that allows accurate assessment of sleep duration and awakening time, without confining patients to a sleep laboratory. Our aim was to compare principal reflux characteristics during the upright, recumbent-awake, and recumbent-asleep periods as well as to determine the effect of sleep awakenings on the principal reflux characteristics of the recumbent-asleep period using novel technology that allows integration of recorded actigraphy data into collected pH information.METHODS: Patients with heartburn at least three times a week for the previous 3 months were invited to participate in this study. All participants were evaluated by the demographics and the GERD Symptom Checklist questionnaires. Thereafter, patients underwent ambulatory 24-h esophageal pH monitoring concomitantly with actigraphy. A novel technique was used to superimpose simultaneously recorded raw actigraphy data over pH data, resulting in more accurate information about reflux events during upright, recumbent-awake, recumbent-asleep, and conscious awakening periods as well as the relationship between symptoms and acid reflux events in the aforementioned periods.RESULTS: Thirty-nine subjects (M/F: 26/13, mean age 56.614 years) with an abnormal pH test were enrolled into the study. The recumbent period appeared heterogeneous and was clearly divided into recumbent-awake (123.020.2 min) and recumbent-asleep (485.623.6 min) periods. The percent total time pH4, the mean number of acid reflux events, and the number of symptoms associated with reflux events were significantly greater in the recumbent-awake as compared with the recumbent-asleep period. The mean duration of an acid reflux event was not different among upright, recumbent-awake, and recumbent-asleep periods. However, short-duration reflux events during the sleep period were associated with conscious awakenings as compared with those during sleep (0.740.11 min vs. 1.640.3 min, P0.01).CONCLUSIONS: The recumbent period is divided into recumbent-awake and recumbent-asleep periods. The recumbent-awake period has significantly different principal reflux characteristics than the recumbent-asleep period. Duration of an acid reflux event during the recumbent-asleep period is not uniformly prolonged. Short-duration acid reflux events during the sleep period are likely due to conscious awakenings.

AB - OBJECTIVES: Characterization of gastroesophageal reflux (GERD) events during the sleep period has been hampered by lack of any patient-friendly technique that allows accurate assessment of sleep duration and awakening time, without confining patients to a sleep laboratory. Our aim was to compare principal reflux characteristics during the upright, recumbent-awake, and recumbent-asleep periods as well as to determine the effect of sleep awakenings on the principal reflux characteristics of the recumbent-asleep period using novel technology that allows integration of recorded actigraphy data into collected pH information.METHODS: Patients with heartburn at least three times a week for the previous 3 months were invited to participate in this study. All participants were evaluated by the demographics and the GERD Symptom Checklist questionnaires. Thereafter, patients underwent ambulatory 24-h esophageal pH monitoring concomitantly with actigraphy. A novel technique was used to superimpose simultaneously recorded raw actigraphy data over pH data, resulting in more accurate information about reflux events during upright, recumbent-awake, recumbent-asleep, and conscious awakening periods as well as the relationship between symptoms and acid reflux events in the aforementioned periods.RESULTS: Thirty-nine subjects (M/F: 26/13, mean age 56.614 years) with an abnormal pH test were enrolled into the study. The recumbent period appeared heterogeneous and was clearly divided into recumbent-awake (123.020.2 min) and recumbent-asleep (485.623.6 min) periods. The percent total time pH4, the mean number of acid reflux events, and the number of symptoms associated with reflux events were significantly greater in the recumbent-awake as compared with the recumbent-asleep period. The mean duration of an acid reflux event was not different among upright, recumbent-awake, and recumbent-asleep periods. However, short-duration reflux events during the sleep period were associated with conscious awakenings as compared with those during sleep (0.740.11 min vs. 1.640.3 min, P0.01).CONCLUSIONS: The recumbent period is divided into recumbent-awake and recumbent-asleep periods. The recumbent-awake period has significantly different principal reflux characteristics than the recumbent-asleep period. Duration of an acid reflux event during the recumbent-asleep period is not uniformly prolonged. Short-duration acid reflux events during the sleep period are likely due to conscious awakenings.

UR - http://www.scopus.com/inward/record.url?scp=77951974067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951974067&partnerID=8YFLogxK

U2 - 10.1038/ajg.2009.636

DO - 10.1038/ajg.2009.636

M3 - Article

C2 - 19904242

AN - SCOPUS:77951974067

VL - 105

SP - 1024

EP - 1031

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 5

ER -