Recall antigen delayed-type hypersensitivity skin testing in melanoma and acute leukemia patients and their associates

D. L. Morris, Evan M Hersh, B. P. Hsi, J. U. Gutterman, M. M. Marshall, G. M. Mavligit

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Patients with malignant melanoma and acute leukemia and their relatives and other associates were screened as potential transfer factor donors and recipients with a battery of four recall, delayed-type hypersensitivity skin test antigens. The skin test results of 336 associates and 179 patients were compared by a variety of techniques, including converting the response in mm to a response score of 0 to 3. There was considerable variation in the response of the associates, 5% being anergic. There was a significant age variation in response to dermatophytin, streptokinase-streptodornase, and Candida (both increases and decreases with age) while purified protein derivative showed no such variation. Taking age into account, the response of Stage IV melanoma patients and acute leukemia patients was lower than that of the normal subjects, while the Stage III melanoma patients had slightly greater responses than did the normals. The antigens most useful in differentiating between groups were Candida and dermatophytin, as well as an overall index of response which reflected the level of response to all the antigens. In a matched comparison of patients and their spouses, the same trends were evident. Comparison of melanoma patients' siblings to other associate groups identified the siblings as low responders. This difference was highly significant for the index of overall response. This was not seen in siblings of leukemia patients. The importance of a well-matched control group of normal subjects for immunological studies of delayed-type hypersensitivity in cancer patients is discussed. Utilization of nonage- and nonenvironment-matched controls is to be discouraged.

Original languageEnglish (US)
Pages (from-to)219-226
Number of pages8
JournalCancer Research
Volume39
Issue number1
StatePublished - 1979
Externally publishedYes

Fingerprint

Delayed Hypersensitivity
Melanoma
Leukemia
Antigens
Skin
Siblings
Skin Tests
Candida
Streptodornase and Streptokinase
Transfer Factor
Spouses
Research Design
Control Groups

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Morris, D. L., Hersh, E. M., Hsi, B. P., Gutterman, J. U., Marshall, M. M., & Mavligit, G. M. (1979). Recall antigen delayed-type hypersensitivity skin testing in melanoma and acute leukemia patients and their associates. Cancer Research, 39(1), 219-226.

Recall antigen delayed-type hypersensitivity skin testing in melanoma and acute leukemia patients and their associates. / Morris, D. L.; Hersh, Evan M; Hsi, B. P.; Gutterman, J. U.; Marshall, M. M.; Mavligit, G. M.

In: Cancer Research, Vol. 39, No. 1, 1979, p. 219-226.

Research output: Contribution to journalArticle

Morris, DL, Hersh, EM, Hsi, BP, Gutterman, JU, Marshall, MM & Mavligit, GM 1979, 'Recall antigen delayed-type hypersensitivity skin testing in melanoma and acute leukemia patients and their associates', Cancer Research, vol. 39, no. 1, pp. 219-226.
Morris, D. L. ; Hersh, Evan M ; Hsi, B. P. ; Gutterman, J. U. ; Marshall, M. M. ; Mavligit, G. M. / Recall antigen delayed-type hypersensitivity skin testing in melanoma and acute leukemia patients and their associates. In: Cancer Research. 1979 ; Vol. 39, No. 1. pp. 219-226.
@article{77620f00449a41ea97d11e000b48a49b,
title = "Recall antigen delayed-type hypersensitivity skin testing in melanoma and acute leukemia patients and their associates",
abstract = "Patients with malignant melanoma and acute leukemia and their relatives and other associates were screened as potential transfer factor donors and recipients with a battery of four recall, delayed-type hypersensitivity skin test antigens. The skin test results of 336 associates and 179 patients were compared by a variety of techniques, including converting the response in mm to a response score of 0 to 3. There was considerable variation in the response of the associates, 5{\%} being anergic. There was a significant age variation in response to dermatophytin, streptokinase-streptodornase, and Candida (both increases and decreases with age) while purified protein derivative showed no such variation. Taking age into account, the response of Stage IV melanoma patients and acute leukemia patients was lower than that of the normal subjects, while the Stage III melanoma patients had slightly greater responses than did the normals. The antigens most useful in differentiating between groups were Candida and dermatophytin, as well as an overall index of response which reflected the level of response to all the antigens. In a matched comparison of patients and their spouses, the same trends were evident. Comparison of melanoma patients' siblings to other associate groups identified the siblings as low responders. This difference was highly significant for the index of overall response. This was not seen in siblings of leukemia patients. The importance of a well-matched control group of normal subjects for immunological studies of delayed-type hypersensitivity in cancer patients is discussed. Utilization of nonage- and nonenvironment-matched controls is to be discouraged.",
author = "Morris, {D. L.} and Hersh, {Evan M} and Hsi, {B. P.} and Gutterman, {J. U.} and Marshall, {M. M.} and Mavligit, {G. M.}",
year = "1979",
language = "English (US)",
volume = "39",
pages = "219--226",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "1",

}

TY - JOUR

T1 - Recall antigen delayed-type hypersensitivity skin testing in melanoma and acute leukemia patients and their associates

AU - Morris, D. L.

AU - Hersh, Evan M

AU - Hsi, B. P.

AU - Gutterman, J. U.

AU - Marshall, M. M.

AU - Mavligit, G. M.

PY - 1979

Y1 - 1979

N2 - Patients with malignant melanoma and acute leukemia and their relatives and other associates were screened as potential transfer factor donors and recipients with a battery of four recall, delayed-type hypersensitivity skin test antigens. The skin test results of 336 associates and 179 patients were compared by a variety of techniques, including converting the response in mm to a response score of 0 to 3. There was considerable variation in the response of the associates, 5% being anergic. There was a significant age variation in response to dermatophytin, streptokinase-streptodornase, and Candida (both increases and decreases with age) while purified protein derivative showed no such variation. Taking age into account, the response of Stage IV melanoma patients and acute leukemia patients was lower than that of the normal subjects, while the Stage III melanoma patients had slightly greater responses than did the normals. The antigens most useful in differentiating between groups were Candida and dermatophytin, as well as an overall index of response which reflected the level of response to all the antigens. In a matched comparison of patients and their spouses, the same trends were evident. Comparison of melanoma patients' siblings to other associate groups identified the siblings as low responders. This difference was highly significant for the index of overall response. This was not seen in siblings of leukemia patients. The importance of a well-matched control group of normal subjects for immunological studies of delayed-type hypersensitivity in cancer patients is discussed. Utilization of nonage- and nonenvironment-matched controls is to be discouraged.

AB - Patients with malignant melanoma and acute leukemia and their relatives and other associates were screened as potential transfer factor donors and recipients with a battery of four recall, delayed-type hypersensitivity skin test antigens. The skin test results of 336 associates and 179 patients were compared by a variety of techniques, including converting the response in mm to a response score of 0 to 3. There was considerable variation in the response of the associates, 5% being anergic. There was a significant age variation in response to dermatophytin, streptokinase-streptodornase, and Candida (both increases and decreases with age) while purified protein derivative showed no such variation. Taking age into account, the response of Stage IV melanoma patients and acute leukemia patients was lower than that of the normal subjects, while the Stage III melanoma patients had slightly greater responses than did the normals. The antigens most useful in differentiating between groups were Candida and dermatophytin, as well as an overall index of response which reflected the level of response to all the antigens. In a matched comparison of patients and their spouses, the same trends were evident. Comparison of melanoma patients' siblings to other associate groups identified the siblings as low responders. This difference was highly significant for the index of overall response. This was not seen in siblings of leukemia patients. The importance of a well-matched control group of normal subjects for immunological studies of delayed-type hypersensitivity in cancer patients is discussed. Utilization of nonage- and nonenvironment-matched controls is to be discouraged.

UR - http://www.scopus.com/inward/record.url?scp=0018758237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018758237&partnerID=8YFLogxK

M3 - Article

C2 - 761192

AN - SCOPUS:0018758237

VL - 39

SP - 219

EP - 226

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 1

ER -