Recent advances in CMV tropism, latency, and diagnosis during aging

Sean X. Leng, Jeremy Kamil, John G. Purdy, Niels A. Lemmermann, Matthias J. Reddehase, Felicia Goodrum

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Human cytomegalovirus (CMV) is one of the largest viruses known to cause human diseases. Chronic CMV infection, as defined by anti-CMV IgG serology, increases with age and is highly prevalent in older adults. It has complex biology with significant immunologic and health consequences. This article aims to summarize research findings presented at the 6th International Workshop on CMV and Immunosenescence that relate to advances in the areas of CMV tropism, latency, CMV manipulation of cell metabolism, and T cell memory inflation, as well as novel diagnostic evaluation and translational research of chronic CMV infection in older adults. Information summarized here represents the current state of knowledge in these important fields. Investigators have also identified a number of areas that deserve further and more in-depth investigation, including building more precise parallels between mouse CMV (mCMV) and human CMV (HCMV) research. It is hoped that this article will also stimulate engaging discussion on strategies and direction to advance the science to the next level.

Original languageEnglish (US)
Pages (from-to)251-259
Number of pages9
JournalGeroScience
Volume39
Issue number3
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Keywords

  • Aging
  • CMV tropism
  • Diagnosis
  • Latency

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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  • Cite this

    Leng, S. X., Kamil, J., Purdy, J. G., Lemmermann, N. A., Reddehase, M. J., & Goodrum, F. (2017). Recent advances in CMV tropism, latency, and diagnosis during aging. GeroScience, 39(3), 251-259. https://doi.org/10.1007/s11357-017-9985-7