Recent advances in cryptococcosis, candidiasis and coccidioidomycosis complicating HIV infection

R. Kappe, S. Levitz, T. S. Harrison, M. Ruhnke, Neil M. Ampel

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Concomitant with the decline in CD4+ T-cells seen as human immunodeficiency virus (HIV) infection progresses, the prevalence of opportunistic mycoses increases dramatically. This article reviews selected recent advances in our understanding of the immunology, molecular epidemiology and treatment of fungal infections in patients infected with HIV. For cryptococcosis, studies are reported on how HIV infection affects the immune response to Cryptococcus neoformans and, conversely, how stimulation with C. neoformans induces HIV production from latently HIV-infected cells. In addition, studies are presented examining the efficacy of triple combination antimycotic chemotherapy in cryptococcosis. For candidosis, investigations into genetic profiles of Candida albicans isolates obtained from patients, with resistance to antifungal agents, are demonstrated. Finally, for coccidioidomycosis, prospective studies are presented examining the clinical, epidemiological and immunological characteristics of a cohort of HIV-infected subjects residing in an endemic area.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalJournal of Medical and Veterinary Mycology
Volume3
StatePublished - 1998

Fingerprint

Coccidioidomycosis
Cryptococcosis
Candidiasis
Virus Diseases
HIV
Cryptococcus neoformans
Mycoses
Molecular Epidemiology
Antifungal Agents
Allergy and Immunology
Combination Drug Therapy
Candida albicans
Prospective Studies
T-Lymphocytes

Keywords

  • Antifungal
  • Fungus
  • Interleukin-12
  • Molecular typing
  • Mononuclear cells
  • Susceptibility testing

ASJC Scopus subject areas

  • Microbiology

Cite this

Recent advances in cryptococcosis, candidiasis and coccidioidomycosis complicating HIV infection. / Kappe, R.; Levitz, S.; Harrison, T. S.; Ruhnke, M.; Ampel, Neil M.

In: Journal of Medical and Veterinary Mycology, Vol. 3, 1998, p. 207-215.

Research output: Contribution to journalArticle

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