Recent Advances in Multicomponent Reaction Chemistry

Applications in Small Molecule Drug Discovery

Christopher Hulme, Muhammad Ayaz, Guillermo Martinez-Ariza, Federico Medda, Arthur Shaw

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Citations (Scopus)

Abstract

The efficiency of translational small molecule medicinal chemistry campaigns is directly related to the "iterative speed" of the skilled drug hunter. Modern-day file enhancement strategies aim to incorporate compounds possessing fragment-, lead-, or drug-like properties measured by a variety of metrics that have been constantly evolving. This chapter discusses the pros and cons of employing multicomponent reactions (MCRs) to enhance the molecular diversity of in-house screening collections and expedite forward progression of lead molecules toward key milestones associated with "drugging" macromolecular targets of interest for therapeutic benefit. It focuses heavily on both well-established MCRs in the pharmaceutical arena (Passerini reaction, Ugi reaction, Van Leusen reaction, Petasis reaction, and Groebke-Blackburn-Bienaymé (GBB) reaction) and recently discovered enticing reactions, including asymmetric versions. The chemistry underpinning these transformations are also discussed with reference to their biological relevance. The chapter pays particular attention to MCRs utilized to discover clinical candidates or marketed drugs.

Original languageEnglish (US)
Title of host publicationSmall Molecule Medicinal Chemistry: Strategies and Technologies
PublisherWiley Blackwell
Pages145-187
Number of pages43
ISBN (Print)9781118771723, 9781118771600
DOIs
StatePublished - Oct 23 2015

Fingerprint

Drug Discovery
Molecules
Pharmaceutical Preparations
Drug products
Screening
Lead
Pharmaceutical Chemistry
Therapeutics

Keywords

  • Asymetric MCRs
  • Classical MCRs
  • Multicomponent reaction chemistry
  • Novel MCRs
  • Small molecule drug discovery

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hulme, C., Ayaz, M., Martinez-Ariza, G., Medda, F., & Shaw, A. (2015). Recent Advances in Multicomponent Reaction Chemistry: Applications in Small Molecule Drug Discovery. In Small Molecule Medicinal Chemistry: Strategies and Technologies (pp. 145-187). Wiley Blackwell. https://doi.org/10.1002/9781118771723.ch6

Recent Advances in Multicomponent Reaction Chemistry : Applications in Small Molecule Drug Discovery. / Hulme, Christopher; Ayaz, Muhammad; Martinez-Ariza, Guillermo; Medda, Federico; Shaw, Arthur.

Small Molecule Medicinal Chemistry: Strategies and Technologies. Wiley Blackwell, 2015. p. 145-187.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hulme, C, Ayaz, M, Martinez-Ariza, G, Medda, F & Shaw, A 2015, Recent Advances in Multicomponent Reaction Chemistry: Applications in Small Molecule Drug Discovery. in Small Molecule Medicinal Chemistry: Strategies and Technologies. Wiley Blackwell, pp. 145-187. https://doi.org/10.1002/9781118771723.ch6
Hulme C, Ayaz M, Martinez-Ariza G, Medda F, Shaw A. Recent Advances in Multicomponent Reaction Chemistry: Applications in Small Molecule Drug Discovery. In Small Molecule Medicinal Chemistry: Strategies and Technologies. Wiley Blackwell. 2015. p. 145-187 https://doi.org/10.1002/9781118771723.ch6
Hulme, Christopher ; Ayaz, Muhammad ; Martinez-Ariza, Guillermo ; Medda, Federico ; Shaw, Arthur. / Recent Advances in Multicomponent Reaction Chemistry : Applications in Small Molecule Drug Discovery. Small Molecule Medicinal Chemistry: Strategies and Technologies. Wiley Blackwell, 2015. pp. 145-187
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