Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation

Patrick W Mantyh, Eric DeMaster, Amit Malhotra, Joseph R. Ghilardi, Scott D. Rogers, Christopher R. Mantyh, Hantao Liu, Allan I. Basbaum, Steven R. Vigna, John E. Maggio, Donald A. Simone

Research output: Contribution to journalArticle

411 Citations (Scopus)

Abstract

In vivo somatosensory stimuli evoked the release of substance P from primary afferent neurons that terminate in the spinal cord and stimulated endocytosis of substance P receptors in rat spinal cord neurons. The distal dendrites that showed substance P receptor internalization underwent morphological reorganization, changing from a tubular structure to one characterized by swollen varicosities connected by thin segments. This internalization and dendritic structural reorganization provided a specific image of neurons activated by substance P. Thus receptor internalization can drive reversible structural changes in central nervous system neurons in vivo. Both of these processes may be involved in neuronal plasticity.

Original languageEnglish (US)
Pages (from-to)1629-1632
Number of pages4
JournalScience
Volume268
Issue number5217
StatePublished - 1995
Externally publishedYes

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Neurokinin-1 Receptors
Dendrites
Endocytosis
Neurons
Spinal Cord
Afferent Neurons
Neuronal Plasticity
Substance P
Central Nervous System

ASJC Scopus subject areas

  • General

Cite this

Mantyh, P. W., DeMaster, E., Malhotra, A., Ghilardi, J. R., Rogers, S. D., Mantyh, C. R., ... Simone, D. A. (1995). Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science, 268(5217), 1629-1632.

Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. / Mantyh, Patrick W; DeMaster, Eric; Malhotra, Amit; Ghilardi, Joseph R.; Rogers, Scott D.; Mantyh, Christopher R.; Liu, Hantao; Basbaum, Allan I.; Vigna, Steven R.; Maggio, John E.; Simone, Donald A.

In: Science, Vol. 268, No. 5217, 1995, p. 1629-1632.

Research output: Contribution to journalArticle

Mantyh, PW, DeMaster, E, Malhotra, A, Ghilardi, JR, Rogers, SD, Mantyh, CR, Liu, H, Basbaum, AI, Vigna, SR, Maggio, JE & Simone, DA 1995, 'Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation', Science, vol. 268, no. 5217, pp. 1629-1632.
Mantyh PW, DeMaster E, Malhotra A, Ghilardi JR, Rogers SD, Mantyh CR et al. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science. 1995;268(5217):1629-1632.
Mantyh, Patrick W ; DeMaster, Eric ; Malhotra, Amit ; Ghilardi, Joseph R. ; Rogers, Scott D. ; Mantyh, Christopher R. ; Liu, Hantao ; Basbaum, Allan I. ; Vigna, Steven R. ; Maggio, John E. ; Simone, Donald A. / Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. In: Science. 1995 ; Vol. 268, No. 5217. pp. 1629-1632.
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