Receptors for octopamine in the storage lobe of the locust (Locusta migratoria) corpus cardiacum

Evidence from studies on cyclic nucleotides

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Abstract

The storage lobe of the locust corpus cardiacum consists primarily of neurosecretory cell axons and terminals and serves as a neurohaemal organ for the release of several neuropeptides. Biogenic amines have previously been identified in the storage lobe of the adult corpus cardiacum, and interest in the functional roles of these amines has arisen due to their modulatory actions on numerous physiological processes in insects. It has been suggested that these compounds may be released from the storage lobe as neurohormones, however an alternative possibility is that they serve as neurotransmitters or neuromodulators which act at sites within the corpus cardiacum proper. The present studies were undertaken to determine if specific amine receptor-adenylate cyclases exist in the storage lobe. Octopamine increases the cAMP content of intact cells in the storage lobes of adult and 5th-instar locusts. Forskolin and 5-HT also enhance cAMP levels in the storage lobe however additivity experiments suggest that 5-HT may be interacting with octopamine binding sites. Dopamine is a poor agonist and norepinephrine has no effect on cAMP content. In adult storage lobes octopamine acts on receptors that have pharmacological similarities to octopamine receptors of identified octopaminergic systems. There thus appears to be an octopamine receptor-adenylate cyclase complex in this tissue. These results suggest that octopamine may be involved in regulating some aspect of neurosecretion in the storage lobe of the locust corpus cardiacum. In addition, significantly higher levels of cGMP were found in the storage lobe compared to those reported for the neighbouring glandular lobe, indicating a possible functional role for this cyclic nucleotide.

Original languageEnglish (US)
Pages (from-to)815-820
Number of pages6
JournalJournal of Insect Physiology
Volume34
Issue number8
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Corpora Allata
Octopamine
Locusta migratoria
octopamine
corpora cardiaca
cyclic nucleotides
Cyclic Nucleotides
Neurotransmitter Agents
receptors
Adenylyl Cyclases
Amines
Serotonin
Neurosecretion
Physiological Phenomena
Grasshoppers
Biogenic Amines
Presynaptic Terminals
adenylate cyclase
Colforsin
Neuropeptides

Keywords

  • corpus cardiacum
  • cyclic AMP
  • cyclic GMP
  • Insect
  • locust
  • neuroendocrine
  • octopamine
  • receptors

ASJC Scopus subject areas

  • Insect Science
  • Physiology

Cite this

@article{ca36a8c95ff640d8b0bcbc8b16d55f0b,
title = "Receptors for octopamine in the storage lobe of the locust (Locusta migratoria) corpus cardiacum: Evidence from studies on cyclic nucleotides",
abstract = "The storage lobe of the locust corpus cardiacum consists primarily of neurosecretory cell axons and terminals and serves as a neurohaemal organ for the release of several neuropeptides. Biogenic amines have previously been identified in the storage lobe of the adult corpus cardiacum, and interest in the functional roles of these amines has arisen due to their modulatory actions on numerous physiological processes in insects. It has been suggested that these compounds may be released from the storage lobe as neurohormones, however an alternative possibility is that they serve as neurotransmitters or neuromodulators which act at sites within the corpus cardiacum proper. The present studies were undertaken to determine if specific amine receptor-adenylate cyclases exist in the storage lobe. Octopamine increases the cAMP content of intact cells in the storage lobes of adult and 5th-instar locusts. Forskolin and 5-HT also enhance cAMP levels in the storage lobe however additivity experiments suggest that 5-HT may be interacting with octopamine binding sites. Dopamine is a poor agonist and norepinephrine has no effect on cAMP content. In adult storage lobes octopamine acts on receptors that have pharmacological similarities to octopamine receptors of identified octopaminergic systems. There thus appears to be an octopamine receptor-adenylate cyclase complex in this tissue. These results suggest that octopamine may be involved in regulating some aspect of neurosecretion in the storage lobe of the locust corpus cardiacum. In addition, significantly higher levels of cGMP were found in the storage lobe compared to those reported for the neighbouring glandular lobe, indicating a possible functional role for this cyclic nucleotide.",
keywords = "corpus cardiacum, cyclic AMP, cyclic GMP, Insect, locust, neuroendocrine, octopamine, receptors",
author = "Pannabecker, {Thomas L} and Ian Orchard",
year = "1988",
doi = "10.1016/0022-1910(88)90156-4",
language = "English (US)",
volume = "34",
pages = "815--820",
journal = "Journal of Insect Physiology",
issn = "0022-1910",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - Receptors for octopamine in the storage lobe of the locust (Locusta migratoria) corpus cardiacum

T2 - Evidence from studies on cyclic nucleotides

AU - Pannabecker, Thomas L

AU - Orchard, Ian

PY - 1988

Y1 - 1988

N2 - The storage lobe of the locust corpus cardiacum consists primarily of neurosecretory cell axons and terminals and serves as a neurohaemal organ for the release of several neuropeptides. Biogenic amines have previously been identified in the storage lobe of the adult corpus cardiacum, and interest in the functional roles of these amines has arisen due to their modulatory actions on numerous physiological processes in insects. It has been suggested that these compounds may be released from the storage lobe as neurohormones, however an alternative possibility is that they serve as neurotransmitters or neuromodulators which act at sites within the corpus cardiacum proper. The present studies were undertaken to determine if specific amine receptor-adenylate cyclases exist in the storage lobe. Octopamine increases the cAMP content of intact cells in the storage lobes of adult and 5th-instar locusts. Forskolin and 5-HT also enhance cAMP levels in the storage lobe however additivity experiments suggest that 5-HT may be interacting with octopamine binding sites. Dopamine is a poor agonist and norepinephrine has no effect on cAMP content. In adult storage lobes octopamine acts on receptors that have pharmacological similarities to octopamine receptors of identified octopaminergic systems. There thus appears to be an octopamine receptor-adenylate cyclase complex in this tissue. These results suggest that octopamine may be involved in regulating some aspect of neurosecretion in the storage lobe of the locust corpus cardiacum. In addition, significantly higher levels of cGMP were found in the storage lobe compared to those reported for the neighbouring glandular lobe, indicating a possible functional role for this cyclic nucleotide.

AB - The storage lobe of the locust corpus cardiacum consists primarily of neurosecretory cell axons and terminals and serves as a neurohaemal organ for the release of several neuropeptides. Biogenic amines have previously been identified in the storage lobe of the adult corpus cardiacum, and interest in the functional roles of these amines has arisen due to their modulatory actions on numerous physiological processes in insects. It has been suggested that these compounds may be released from the storage lobe as neurohormones, however an alternative possibility is that they serve as neurotransmitters or neuromodulators which act at sites within the corpus cardiacum proper. The present studies were undertaken to determine if specific amine receptor-adenylate cyclases exist in the storage lobe. Octopamine increases the cAMP content of intact cells in the storage lobes of adult and 5th-instar locusts. Forskolin and 5-HT also enhance cAMP levels in the storage lobe however additivity experiments suggest that 5-HT may be interacting with octopamine binding sites. Dopamine is a poor agonist and norepinephrine has no effect on cAMP content. In adult storage lobes octopamine acts on receptors that have pharmacological similarities to octopamine receptors of identified octopaminergic systems. There thus appears to be an octopamine receptor-adenylate cyclase complex in this tissue. These results suggest that octopamine may be involved in regulating some aspect of neurosecretion in the storage lobe of the locust corpus cardiacum. In addition, significantly higher levels of cGMP were found in the storage lobe compared to those reported for the neighbouring glandular lobe, indicating a possible functional role for this cyclic nucleotide.

KW - corpus cardiacum

KW - cyclic AMP

KW - cyclic GMP

KW - Insect

KW - locust

KW - neuroendocrine

KW - octopamine

KW - receptors

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U2 - 10.1016/0022-1910(88)90156-4

DO - 10.1016/0022-1910(88)90156-4

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EP - 820

JO - Journal of Insect Physiology

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