Receptors for sensory neuropeptides in human inflammatory diseases: Implications for the effector role of sensory neurons

Patrick W Mantyh, M. D. Catton, C. G. Boehmer, M. L. Welton, E. P. Passaro, J. E. Maggio, S. R. Vigna

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Glutamate and several neuropeptides are synthesized and released by subpopulations of primary afferent neurons. These sensory neurons play a role in regulating the inflammatory and immune responses in peripheral tissues. Using quantitative receptor autoradiography we have explored what changes occur in the location and concentration of receptor binding sites for sensory neurotransmitters in the colon in two human inflammatory diseases, ulcerative colitis and Crohn's disease. The sensory neurotransmitter receptors examined included bombesin, calcitonin gene related peptide-α, cholecystokinin, galanin, glutamate, somatostatin, neurokinin A (substance K), substance P, and vasoactive intestinal polypeptide. Of the nine receptor binding sites examined only substance P binding sites associated with arterioles, venules and lymph nodules were dramatically up-regulated in the inflamed tissue. These data suggest that substance P is involved in regulating the inflammatory and immune responses in human inflammatory diseases and indicate a specificity of efferent action for each sensory neurotransmitter in peripheral tissues.

Original languageEnglish (US)
Pages (from-to)627-645
Number of pages19
JournalPeptides
Volume10
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Neuropeptide Receptors
Sensory Receptor Cells
Substance P
Neuropeptides
Neurons
Neurokinin A
Binding Sites
Tissue
Neurotransmitter Agents
Glutamic Acid
Galanin
Afferent Neurons
Bombesin
Neurotransmitter Receptor
Venules
Calcitonin Gene-Related Peptide
Vasoactive Intestinal Peptide
Cholecystokinin
Arterioles
Lymph

Keywords

  • Inflammatory bowel disease
  • Receptors
  • Sensory neuropeptides
  • Substance P
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Receptors for sensory neuropeptides in human inflammatory diseases : Implications for the effector role of sensory neurons. / Mantyh, Patrick W; Catton, M. D.; Boehmer, C. G.; Welton, M. L.; Passaro, E. P.; Maggio, J. E.; Vigna, S. R.

In: Peptides, Vol. 10, No. 3, 1989, p. 627-645.

Research output: Contribution to journalArticle

Mantyh, Patrick W ; Catton, M. D. ; Boehmer, C. G. ; Welton, M. L. ; Passaro, E. P. ; Maggio, J. E. ; Vigna, S. R. / Receptors for sensory neuropeptides in human inflammatory diseases : Implications for the effector role of sensory neurons. In: Peptides. 1989 ; Vol. 10, No. 3. pp. 627-645.
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