Reconstructing human origins in the genomic era

Daniel Garrigan, Michael F. Hammer

Research output: Contribution to journalReview article

167 Scopus citations

Abstract

Analyses of recently acquired genomic sequence data are leading to important insights into the early evolution of anatomically modern humans, as well as into the more recent demographic processes that accompanied the global radiation of Homo sapiens. Some of the new results contradict early, but still influential, conclusions that were based on analyses of gene trees from mitochondrial DNA and Y-chromosome sequences. In this review, we discuss the different genetic and statistical methods that are available for studying human population history, and identify the most plausible models of human evolution that can accommodate the contrasting patterns observed at different loci throughout the genome.

Original languageEnglish (US)
Pages (from-to)669-680
Number of pages12
JournalNature Reviews Genetics
Volume7
Issue number9
DOIs
StatePublished - Sep 8 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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