Recurrent coagulopathy after antivenom treatment of crotalid snakebite

Gregory M. Bogdan, Richard C. Dart, Steve C. Falbo, Jude McNally, Daniel W Spaite

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background. We studied whether recurrence of coagulopathy, defined as the return of a coagulation abnormality after initial normalization, occurred after the use of antivenin (Crotalidae) polyvalent. Methods. A retrospective, blinded, descriptive analysis of 354 consecutive cases of North American crotalid snake envenomation was done. Inclusion criteria were documented clinical evidence of crotalid snakebite, presence of a coagulopathy (platelet count < 150,000/mm3, prothrombin time above normal, or fibrinogen level <150 mg/dL), and treatment with antivenin (Crotalidae) polyvalent. Results. Of 112 cases with a coagulopathy extending beyond 6 hours after envenomation, 31 had sufficient coagulopathy testing to detect recurrence. Fourteen of these patients (45%) had recurrence of coagulopathy, and two cases were severe (fibrinogen level 29 mg/dL; platelet count 36,000/mm3). Conclusion. Recurrence of coagulopathy after envenomation by North American crotalid snakes may occur after use of antivenin (Crotalidae) polyvalent and can result in severe coagulation abnormalities.

Original languageEnglish (US)
Pages (from-to)562-566
Number of pages5
JournalSouthern Medical Journal
Volume93
Issue number6
StatePublished - 2000
Externally publishedYes

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Antivenins
Snake Bites
Viperidae
Recurrence
Platelet Count
Fibrinogen
Snakes
Prothrombin Time
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bogdan, G. M., Dart, R. C., Falbo, S. C., McNally, J., & Spaite, D. W. (2000). Recurrent coagulopathy after antivenom treatment of crotalid snakebite. Southern Medical Journal, 93(6), 562-566.

Recurrent coagulopathy after antivenom treatment of crotalid snakebite. / Bogdan, Gregory M.; Dart, Richard C.; Falbo, Steve C.; McNally, Jude; Spaite, Daniel W.

In: Southern Medical Journal, Vol. 93, No. 6, 2000, p. 562-566.

Research output: Contribution to journalArticle

Bogdan, GM, Dart, RC, Falbo, SC, McNally, J & Spaite, DW 2000, 'Recurrent coagulopathy after antivenom treatment of crotalid snakebite', Southern Medical Journal, vol. 93, no. 6, pp. 562-566.
Bogdan, Gregory M. ; Dart, Richard C. ; Falbo, Steve C. ; McNally, Jude ; Spaite, Daniel W. / Recurrent coagulopathy after antivenom treatment of crotalid snakebite. In: Southern Medical Journal. 2000 ; Vol. 93, No. 6. pp. 562-566.
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