Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations

B. M. Ciminelli, F. Pompei, P. Malaspina, M. Hammer, F. Persichetti, P. F. Pignatti, A. Palena, N. Anagnou, G. Guanti, C. Jodice, L. Terrenato, A. Novelletto

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The haplotypes at four polymorphic loci of theY chromosome were determined in 245 Caucasian males from 12 subpopulations. The data show that haplotype radiation occurred among Caucasians. Haplotype radiation was accompanied by recurrent mutations at STR loci that caused partial randomization of haplotype structure. The present distribution of alleles at short tandem repeats (STRs) can be explained by a mutation pattern similar to those described for autosomal STRs. The degree of variation among groups of subpopulations was assayed by using the Analysis of Molecular Variance. The results confirm a faster divergence of the Y chromosome as compared to the rest of the genome.

Original languageEnglish (US)
Pages (from-to)966-973
Number of pages8
JournalJournal of Molecular Evolution
Volume41
Issue number6
DOIs
StatePublished - Dec 1995
Externally publishedYes

Keywords

  • Human Y chromosome
  • Human radiation
  • Single tandem repeats
  • Y polymorphisms

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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    Ciminelli, B. M., Pompei, F., Malaspina, P., Hammer, M., Persichetti, F., Pignatti, P. F., Palena, A., Anagnou, N., Guanti, G., Jodice, C., Terrenato, L., & Novelletto, A. (1995). Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations. Journal of Molecular Evolution, 41(6), 966-973. https://doi.org/10.1007/BF00173177