Red blood cell alloimmunization in sickle cell disease: Listen to your ancestors

Sally A. Campbell-Lee, Rick A. Kittles

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Red blood cell (RBC) alloimmunization occurs in approximately 30% of transfused sickle cell disease patients compared to 2-5% of all transfusion recipients. Because RBC transfusion is an important part of therapy in sickle cell disease, the need for additional antigen matching once alloimmunization occurs is problematic and leads to therapeutic limitations. Thus, identification of risk factors would benefit this patient population. Genome-wide analyses, in particular, methods which take into account genetic ancestry such as admixture mapping, could identify molecular markers which could be used to identify immune responders to transfusion.

Original languageEnglish (US)
Pages (from-to)431-435
Number of pages5
JournalTransfusion Medicine and Hemotherapy
Volume41
Issue number6
DOIs
StatePublished - Dec 17 2014

Keywords

  • Alloimmunization
  • Ancestry
  • Genome
  • Sickle cell disease
  • Transfusion

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology

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