Red blood cell fragility in acute cerebral ischemia: Effects of calcium ions and flunarizine

Y. Tan, B. M. Coull, R. J. Knox, N. B. Beamer, G. V.F. Seaman, L. Mela-Riker, F. J. Nordt

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The fragility of erythrocytes (RBC) from patients with acute ischemic stroke and from normal age-matched control individuals was compared in the presence of ionomycin and various calcium ion concentrations ranging from 0 to 2.5 mM after filtration through 5 μm pore diameter polycarbonate membranes at 20 cm Hg pressure. At calcium ion concentrations of 0.5 and 1.5 mM, RBC from stroke patients hemolyzed to a greater extent than those obtained from controls. This difference is indicative of abnormal calcium ion homeostasis in RBC obtained from stroke patients. Flunarizine, a calcium ion channel blocker, significantly inhibited the degree of hemolysis of RBC due to calcium loading in both stroke and control groups. These data are consistent with numerous reports showing that calcium ion homeostasis plays a crucial role in governing RBC mechanical properties including cellular deformability.

Original languageEnglish (US)
Pages (from-to)273-280
Number of pages8
JournalClinical Hemorheology
Issue number2
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Hematology


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