Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk

Amit D. Joshi, Román Corral, Kimberly D. Siegmund, Robert W. Haile, Loïlc Le Marchand, Maria Elena Martínez, Dennis J. Ahnen, Robert S. Sandler, Michael P Lance, Mariana C. Stern

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Abstract

Diets high in red meat have been consistently associated with colorectal cancer (CRC) risk and may result in exposure to carcinogens that cause DNA damage [i.e polycyclic aromatic hydrocarbons, heterocyclic amines (HCAs) and N-nitroso compounds]. Using a family-based study, we investigated whether polymorphisms in the nucleotide excision repair (NER) (ERCC1 3′ untranslated region (UTR) G/T, XPD Asp312Asn and Lys751Gln, XPC intron 11 C/A, XPA 5′ UTR C/T, XPF Arg415Gln and XPG Asp1104His) and mismatch repair (MLH1 Ile219Val and MSH2 Gly322Asp) pathways modified the association with red meat and poultry intake. We tested for gene-environment interactions using case-only analyses (n = 577) and compared the results using case-unaffected sibling comparisons (n = 307 sibships). Increased risk of CRC was observed for intake of more than or equal to three servings per week of red meat [odds ratio (OR) = 1.8, 95% confidence interval (CI) = 1.3-2.5)] or high-temperature cooked red meat (OR = 1.6, 95% CI = 1.1-2.2). Intake of red meat heavily brown on the outside or inside increased CRC risk only among subjects who carried the XPD codon 751 Lys/Lys genotype (case-only interaction P = 0.006 and P = 0.001, respectively, for doneness outside or inside) or the XPD codon 312 Asp/Asp genotype (case-only interaction P = 0.090 and P = 0.001, respectively). These interactions were stronger for rectal cancer cases (heterogeneity test P = 0.002 for XPD Asp312Asn and P = 0.03 for XPD Lys751Gln) and remained statistically significant after accounting for multiple testing. Case-unaffected sibling analyses were generally supportive of the case-only results. These findings highlight the possible contribution of diets high in red meat to the formation of lesions that elicit the NER pathway, such as carcinogen-induced bulky adducts.

Original languageEnglish (US)
Pages (from-to)472-479
Number of pages8
JournalCarcinogenesis
Volume30
Issue number3
DOIs
StatePublished - 2009
Externally publishedYes

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DNA Mismatch Repair
Poultry
DNA Repair
Colorectal Neoplasms
Viperidae
Codon
Carcinogens
Odds Ratio
Genotype
Confidence Intervals
Nitroso Compounds
Diet
Gene-Environment Interaction
5' Untranslated Regions
Polycyclic Aromatic Hydrocarbons
3' Untranslated Regions
Rectal Neoplasms
Introns
DNA Damage
Amines

ASJC Scopus subject areas

  • Cancer Research

Cite this

Joshi, A. D., Corral, R., Siegmund, K. D., Haile, R. W., Le Marchand, L., Martínez, M. E., ... Stern, M. C. (2009). Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Carcinogenesis, 30(3), 472-479. https://doi.org/10.1093/carcin/bgn260

Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. / Joshi, Amit D.; Corral, Román; Siegmund, Kimberly D.; Haile, Robert W.; Le Marchand, Loïlc; Martínez, Maria Elena; Ahnen, Dennis J.; Sandler, Robert S.; Lance, Michael P; Stern, Mariana C.

In: Carcinogenesis, Vol. 30, No. 3, 2009, p. 472-479.

Research output: Contribution to journalArticle

Joshi, AD, Corral, R, Siegmund, KD, Haile, RW, Le Marchand, L, Martínez, ME, Ahnen, DJ, Sandler, RS, Lance, MP & Stern, MC 2009, 'Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk', Carcinogenesis, vol. 30, no. 3, pp. 472-479. https://doi.org/10.1093/carcin/bgn260
Joshi, Amit D. ; Corral, Román ; Siegmund, Kimberly D. ; Haile, Robert W. ; Le Marchand, Loïlc ; Martínez, Maria Elena ; Ahnen, Dennis J. ; Sandler, Robert S. ; Lance, Michael P ; Stern, Mariana C. / Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. In: Carcinogenesis. 2009 ; Vol. 30, No. 3. pp. 472-479.
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AU - Le Marchand, Loïlc

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AU - Ahnen, Dennis J.

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