Redox regulation of c-Ha-ras and osteopontin signaling in vascular smooth muscle cells: Implications in chemical atherogenesis

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Reduction/oxidation (redox) reactions play a central role in the regulation of vascular cell functions. Recent studies in this laboratory have identified c-Ha-ras and osteopontin genes as critical molecular targets during oxidant-induced atherogenesis. This review focuses on the deregulation of gene transcription by redox-activated trans-acting factors after benzo(a)pyrene challenge and the modulation of extracellular matrix signaling in vascular smooth muscle cells by allylamine-induced oxidative injury. The induction of atherogenic vascular smooth muscle cell phenotypes by chemical injury exhibits remarkable parallels with those seen in other forms of atherogenesis.

Original languageEnglish (US)
Pages (from-to)243-265
Number of pages23
JournalAnnual Review of Pharmacology and Toxicology
Volume39
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Osteopontin
Vascular Smooth Muscle
Oxidation-Reduction
Smooth Muscle Myocytes
Muscle
Atherosclerosis
Allylamine
Cells
Trans-Activators
ras Genes
Benzo(a)pyrene
Wounds and Injuries
Genes
Oxidants
Extracellular Matrix
Blood Vessels
Deregulation
Redox reactions
Transcription
Phenotype

Keywords

  • Atherosclerosis
  • Cell signaling
  • Extracellular matrix
  • Gene regulation
  • Oxidative injury

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

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