Redox signalling and the control of cell growth and death

Garth Powis, Margaret Briehl, John Oblong

Research output: Contribution to journalReview article

190 Scopus citations

Abstract

Cells maintain a reduced intracellular state in the face of a highly oxidizing extracellular environment. Redox signalling pathways provide a link between external stimuli, through the flavoenzyme-mediated NADPH-dependent reduction of intracellular peptide thiols, such as glutathione, thioredoxin, glutaredoxin, and redox factor-1, to the posttranslational redox modification of certain intracellular proteins. This can affect the proteins' correct folding, assembly into multimeric complexes, enzymatic activity, and their binding as transcription factors to specific DNA sequences. Such changes have been linked to altered cell growth and death.

Original languageEnglish (US)
Pages (from-to)149-173
Number of pages25
JournalPharmacology and Therapeutics
Volume68
Issue number1
DOIs
StatePublished - 1995

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Keywords

  • Redox signalling
  • cell growth
  • glutaredoxin
  • glutathione
  • thioredoxin
  • transcription factors

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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