Reduced micronutrient intake accentuates premature death caused by immune dysfunction in leukemia retrovirus-infected C57BL/6 mice

Jeongmin Lee, Chang Soo Park, Min Young Chung, Dong Hyeok Cho, Ronald R Watson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated the effect of micronutrient deficiency on the survival and immune dysfunction of C57BL/6 mice during progression to murine AIDS. Survival of retrovirus-infected mice has been influenced by micronutrient deficiency although it alone could significantly reduce the median survival time. The premature death could be explained by dysregulation of the immune system and generation of free radicals. Dysfunction of T-cell and B-cell mitogenesis from primary cultured splenocytes has been observed with retrovirus infection and micronutrient deficiency in synergism. There was an abnormal shift of cytokine pattern that was designated by the decreased secretion of Th1 cytokines and increased secretion of Th2 cytokines. The hepatic vitamin E level was significantly decreased by retrovirus infection and micronutrient deficiency, in accordance with the increased hepatic lipid peroxidation level. This study suggests that micronutrient deficiency may accelerate premature death during progression to murine AIDS, implying that nutritional application would be the first line to consider for retarding the progression from HIV infection to AIDS.

Original languageEnglish (US)
Pages (from-to)401-412
Number of pages12
JournalNutrition Research
Volume25
Issue number4
DOIs
StatePublished - Apr 2005

Fingerprint

Premature Mortality
Micronutrients
Retroviridae
Inbred C57BL Mouse
Leukemia
Murine Acquired Immunodeficiency Syndrome
Retroviridae Infections
Cytokines
Liver
Vitamin E
Lipid Peroxidation
Free Radicals
HIV Infections
Immune System
Acquired Immunodeficiency Syndrome
B-Lymphocytes
T-Lymphocytes

Keywords

  • Cytokine
  • Mice
  • Micronutrients
  • Murine AIDS
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Reduced micronutrient intake accentuates premature death caused by immune dysfunction in leukemia retrovirus-infected C57BL/6 mice. / Lee, Jeongmin; Park, Chang Soo; Chung, Min Young; Cho, Dong Hyeok; Watson, Ronald R.

In: Nutrition Research, Vol. 25, No. 4, 04.2005, p. 401-412.

Research output: Contribution to journalArticle

Lee, Jeongmin ; Park, Chang Soo ; Chung, Min Young ; Cho, Dong Hyeok ; Watson, Ronald R. / Reduced micronutrient intake accentuates premature death caused by immune dysfunction in leukemia retrovirus-infected C57BL/6 mice. In: Nutrition Research. 2005 ; Vol. 25, No. 4. pp. 401-412.
@article{b323baea1b404e6b98945973182aa2f3,
title = "Reduced micronutrient intake accentuates premature death caused by immune dysfunction in leukemia retrovirus-infected C57BL/6 mice",
abstract = "We investigated the effect of micronutrient deficiency on the survival and immune dysfunction of C57BL/6 mice during progression to murine AIDS. Survival of retrovirus-infected mice has been influenced by micronutrient deficiency although it alone could significantly reduce the median survival time. The premature death could be explained by dysregulation of the immune system and generation of free radicals. Dysfunction of T-cell and B-cell mitogenesis from primary cultured splenocytes has been observed with retrovirus infection and micronutrient deficiency in synergism. There was an abnormal shift of cytokine pattern that was designated by the decreased secretion of Th1 cytokines and increased secretion of Th2 cytokines. The hepatic vitamin E level was significantly decreased by retrovirus infection and micronutrient deficiency, in accordance with the increased hepatic lipid peroxidation level. This study suggests that micronutrient deficiency may accelerate premature death during progression to murine AIDS, implying that nutritional application would be the first line to consider for retarding the progression from HIV infection to AIDS.",
keywords = "Cytokine, Mice, Micronutrients, Murine AIDS, Oxidative stress",
author = "Jeongmin Lee and Park, {Chang Soo} and Chung, {Min Young} and Cho, {Dong Hyeok} and Watson, {Ronald R}",
year = "2005",
month = "4",
doi = "10.1016/j.nutres.2004.12.010",
language = "English (US)",
volume = "25",
pages = "401--412",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Reduced micronutrient intake accentuates premature death caused by immune dysfunction in leukemia retrovirus-infected C57BL/6 mice

AU - Lee, Jeongmin

AU - Park, Chang Soo

AU - Chung, Min Young

AU - Cho, Dong Hyeok

AU - Watson, Ronald R

PY - 2005/4

Y1 - 2005/4

N2 - We investigated the effect of micronutrient deficiency on the survival and immune dysfunction of C57BL/6 mice during progression to murine AIDS. Survival of retrovirus-infected mice has been influenced by micronutrient deficiency although it alone could significantly reduce the median survival time. The premature death could be explained by dysregulation of the immune system and generation of free radicals. Dysfunction of T-cell and B-cell mitogenesis from primary cultured splenocytes has been observed with retrovirus infection and micronutrient deficiency in synergism. There was an abnormal shift of cytokine pattern that was designated by the decreased secretion of Th1 cytokines and increased secretion of Th2 cytokines. The hepatic vitamin E level was significantly decreased by retrovirus infection and micronutrient deficiency, in accordance with the increased hepatic lipid peroxidation level. This study suggests that micronutrient deficiency may accelerate premature death during progression to murine AIDS, implying that nutritional application would be the first line to consider for retarding the progression from HIV infection to AIDS.

AB - We investigated the effect of micronutrient deficiency on the survival and immune dysfunction of C57BL/6 mice during progression to murine AIDS. Survival of retrovirus-infected mice has been influenced by micronutrient deficiency although it alone could significantly reduce the median survival time. The premature death could be explained by dysregulation of the immune system and generation of free radicals. Dysfunction of T-cell and B-cell mitogenesis from primary cultured splenocytes has been observed with retrovirus infection and micronutrient deficiency in synergism. There was an abnormal shift of cytokine pattern that was designated by the decreased secretion of Th1 cytokines and increased secretion of Th2 cytokines. The hepatic vitamin E level was significantly decreased by retrovirus infection and micronutrient deficiency, in accordance with the increased hepatic lipid peroxidation level. This study suggests that micronutrient deficiency may accelerate premature death during progression to murine AIDS, implying that nutritional application would be the first line to consider for retarding the progression from HIV infection to AIDS.

KW - Cytokine

KW - Mice

KW - Micronutrients

KW - Murine AIDS

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=16844366139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16844366139&partnerID=8YFLogxK

U2 - 10.1016/j.nutres.2004.12.010

DO - 10.1016/j.nutres.2004.12.010

M3 - Article

AN - SCOPUS:16844366139

VL - 25

SP - 401

EP - 412

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 4

ER -