Reduced-size porcine lung transplantation: Long-term studies of pulmonary vascular resistance

John A. Kern, Curtis G. Tribble, Barry B.K. Chan, Terry L. Flanagan, Irving L. Kron

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The use of isolated adult lobes for pediatric lung transplantation has recently been reported and could potentially help alleviate the profound pediatric donor lung shortage. However, the effect of chronic denervation on pulmonary vasculature of isolated mature lobar transplants is not well understood. Previously, we reported that chronic denervation of the immature porcine lobe results in abnormal pulmonary vascular compliance. We now present studies of long-term pulmonary hemodynamics in young pigs 12 weeks after transplantation of a reduced-size mature left lower lobe. Resting pulmonary vascular resistance of the transplanted mature lobes was similar to that of innervated lobes of age-matched controls. In addition, pulmonary vascular resistance of the transplanted mature lobes did not rise abnormally in response to increased flow caused by clamping the contralateral pulmonary artery. We conclude that denervation of the mature porcine lobe does not result in abnormal pulmonary vascular resistance. In addition, vascular compliance of reduced-size mature porcine lobar transplants is superior to that of denervated reimplanted immature lobes. These findings suggest a deleterious effect of denervation on pulmonary vascular development of the growing porcine lung.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalThe Annals of Thoracic Surgery
Volume53
Issue number4
DOIs
StatePublished - Apr 1992
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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