Reduction in fat intake is not associated with weight loss in most women after breast cancer diagnosis: Evidence from a randomized controlled trial

Cheryl L. Rock, Cynthia Thomson, Bette J. Caan, Shirley W. Flatt, Vicky Newman, Cheryl Ritenbaugh, James R. Marshall, Kathryn A. Hollenbach, Marcia L. Stefanick, John P. Pierce

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

BACKGROUND. A reduction in dietary fat intake has been suggested as a method to promote weight loss in women at risk for breast cancer recurrence. METHODS. Weight change in response to diet intervention was examined in 1010 women who had completed treatment for Stage I, Stage II, or Stage IIIA (American Joint Committee on Cancer staging system) primary operable breast cancer during their first year of participation in a randomized, controlled, diet intervention trial to reduce risk of recurrence. Diet intervention was performed by telephone counseling and promoted a low fat diet that also was high in fiber, vegetables, and fruit. The comparison group was provided with general dietary guidelines to reduce disease risk. Multiple linear regression models were used to examine the relations among demographic and personal characteristics, changes in diet composition and exercise level, and change in body weight or body mass index. RESULTS. The average weight change in the 1-year period was 0.04 kg for the intervention group and 0.46 kg for the comparison group. For the total group, body weight was stable (± 5% baseline weight) for 743 women (74%), whereas 114 (11%) lost weight, and 153 (15%) gained weight. These distributions were similar in the two study groups inclusive of all study participants and for only those women with a baseline body mass index of ≥25 kg/m2. Initial body mass index and changes in fiber and vegetable intakes, but not change in percent of energy obtained from fat, were associated independently with change in weight or body mass index. CONCLUSIONS. For most women at risk for breast cancer recurrence, diet intervention to promote a reduction in fat intake was not associated with significant weight loss. Testing the effect of a substantial change in diet composition on risk for breast cancer recurrence is unlikely to be confounded by weight loss in subjects who were the recipients of intensive intervention efforts.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalCancer
Volume91
Issue number1
DOIs
StatePublished - Jan 1 2001

Fingerprint

Weight Loss
Randomized Controlled Trials
Fats
Breast Neoplasms
Diet
Weights and Measures
Body Mass Index
Recurrence
Vegetables
Linear Models
Nutrition Policy
Fat-Restricted Diet
Body Weight Changes
Neoplasm Staging
Dietary Fats
Telephone
Counseling
Fruit
Body Weight
Demography

Keywords

  • Breast cancer
  • Dietary fat
  • Dietary fiber
  • Obesity
  • Weight loss

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Reduction in fat intake is not associated with weight loss in most women after breast cancer diagnosis : Evidence from a randomized controlled trial. / Rock, Cheryl L.; Thomson, Cynthia; Caan, Bette J.; Flatt, Shirley W.; Newman, Vicky; Ritenbaugh, Cheryl; Marshall, James R.; Hollenbach, Kathryn A.; Stefanick, Marcia L.; Pierce, John P.

In: Cancer, Vol. 91, No. 1, 01.01.2001, p. 25-34.

Research output: Contribution to journalArticle

Rock, Cheryl L. ; Thomson, Cynthia ; Caan, Bette J. ; Flatt, Shirley W. ; Newman, Vicky ; Ritenbaugh, Cheryl ; Marshall, James R. ; Hollenbach, Kathryn A. ; Stefanick, Marcia L. ; Pierce, John P. / Reduction in fat intake is not associated with weight loss in most women after breast cancer diagnosis : Evidence from a randomized controlled trial. In: Cancer. 2001 ; Vol. 91, No. 1. pp. 25-34.
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abstract = "BACKGROUND. A reduction in dietary fat intake has been suggested as a method to promote weight loss in women at risk for breast cancer recurrence. METHODS. Weight change in response to diet intervention was examined in 1010 women who had completed treatment for Stage I, Stage II, or Stage IIIA (American Joint Committee on Cancer staging system) primary operable breast cancer during their first year of participation in a randomized, controlled, diet intervention trial to reduce risk of recurrence. Diet intervention was performed by telephone counseling and promoted a low fat diet that also was high in fiber, vegetables, and fruit. The comparison group was provided with general dietary guidelines to reduce disease risk. Multiple linear regression models were used to examine the relations among demographic and personal characteristics, changes in diet composition and exercise level, and change in body weight or body mass index. RESULTS. The average weight change in the 1-year period was 0.04 kg for the intervention group and 0.46 kg for the comparison group. For the total group, body weight was stable (± 5{\%} baseline weight) for 743 women (74{\%}), whereas 114 (11{\%}) lost weight, and 153 (15{\%}) gained weight. These distributions were similar in the two study groups inclusive of all study participants and for only those women with a baseline body mass index of ≥25 kg/m2. Initial body mass index and changes in fiber and vegetable intakes, but not change in percent of energy obtained from fat, were associated independently with change in weight or body mass index. CONCLUSIONS. For most women at risk for breast cancer recurrence, diet intervention to promote a reduction in fat intake was not associated with significant weight loss. Testing the effect of a substantial change in diet composition on risk for breast cancer recurrence is unlikely to be confounded by weight loss in subjects who were the recipients of intensive intervention efforts.",
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AU - Flatt, Shirley W.

AU - Newman, Vicky

AU - Ritenbaugh, Cheryl

AU - Marshall, James R.

AU - Hollenbach, Kathryn A.

AU - Stefanick, Marcia L.

AU - Pierce, John P.

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N2 - BACKGROUND. A reduction in dietary fat intake has been suggested as a method to promote weight loss in women at risk for breast cancer recurrence. METHODS. Weight change in response to diet intervention was examined in 1010 women who had completed treatment for Stage I, Stage II, or Stage IIIA (American Joint Committee on Cancer staging system) primary operable breast cancer during their first year of participation in a randomized, controlled, diet intervention trial to reduce risk of recurrence. Diet intervention was performed by telephone counseling and promoted a low fat diet that also was high in fiber, vegetables, and fruit. The comparison group was provided with general dietary guidelines to reduce disease risk. Multiple linear regression models were used to examine the relations among demographic and personal characteristics, changes in diet composition and exercise level, and change in body weight or body mass index. RESULTS. The average weight change in the 1-year period was 0.04 kg for the intervention group and 0.46 kg for the comparison group. For the total group, body weight was stable (± 5% baseline weight) for 743 women (74%), whereas 114 (11%) lost weight, and 153 (15%) gained weight. These distributions were similar in the two study groups inclusive of all study participants and for only those women with a baseline body mass index of ≥25 kg/m2. Initial body mass index and changes in fiber and vegetable intakes, but not change in percent of energy obtained from fat, were associated independently with change in weight or body mass index. CONCLUSIONS. For most women at risk for breast cancer recurrence, diet intervention to promote a reduction in fat intake was not associated with significant weight loss. Testing the effect of a substantial change in diet composition on risk for breast cancer recurrence is unlikely to be confounded by weight loss in subjects who were the recipients of intensive intervention efforts.

AB - BACKGROUND. A reduction in dietary fat intake has been suggested as a method to promote weight loss in women at risk for breast cancer recurrence. METHODS. Weight change in response to diet intervention was examined in 1010 women who had completed treatment for Stage I, Stage II, or Stage IIIA (American Joint Committee on Cancer staging system) primary operable breast cancer during their first year of participation in a randomized, controlled, diet intervention trial to reduce risk of recurrence. Diet intervention was performed by telephone counseling and promoted a low fat diet that also was high in fiber, vegetables, and fruit. The comparison group was provided with general dietary guidelines to reduce disease risk. Multiple linear regression models were used to examine the relations among demographic and personal characteristics, changes in diet composition and exercise level, and change in body weight or body mass index. RESULTS. The average weight change in the 1-year period was 0.04 kg for the intervention group and 0.46 kg for the comparison group. For the total group, body weight was stable (± 5% baseline weight) for 743 women (74%), whereas 114 (11%) lost weight, and 153 (15%) gained weight. These distributions were similar in the two study groups inclusive of all study participants and for only those women with a baseline body mass index of ≥25 kg/m2. Initial body mass index and changes in fiber and vegetable intakes, but not change in percent of energy obtained from fat, were associated independently with change in weight or body mass index. CONCLUSIONS. For most women at risk for breast cancer recurrence, diet intervention to promote a reduction in fat intake was not associated with significant weight loss. Testing the effect of a substantial change in diet composition on risk for breast cancer recurrence is unlikely to be confounded by weight loss in subjects who were the recipients of intensive intervention efforts.

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KW - Dietary fiber

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