Reduction of lipid-laden macrophage index after laparoscopic Nissen fundoplication in cystic fibrosis patients after lung transplantation

Don Hayes, Stephen Kirkby, Karen S. Mccoy, Heidi M. Mansour, Medhi Khosravi, Heather Strawbridge, Joseph D. Tobias

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: Lipid-laden macrophage (LLM) index could be potentially useful in assessing gastroesophageal (GE) reflux and aspiration after lung transplantation (LT) in patients with cystic fibrosis (CF). Methods: A retrospective review of CF patients undergoing LT and/or laparoscopic Nissen fundoplication (LNF) from January 1, 2009, to December 31, 2011, was performed. Results: Seventeen CF patients (nine women), mean (±SD) age 27.9 ± 7.5 yr, underwent LT with mean (±SD) pre-transplant FEV1 of 20.9 ± 5.0% predicted. Seventy percentage (12/17) of patients underwent LNF without complications within 1-2 wk of LT. After LT, but prior to antireflux surgery, there was no significant difference in the mean (±SD) baseline LLM index (154 ± 41 vs. 146 ± 51, p = NS) between patients who were to undergo LNF and patients who did not. After LNF, a significant reduction in the mean (±SD) LLM index occurred following the procedure (154 ± 41-74 ± 54, p < 0.0001) while each patient reported resolution of symptoms of GE reflux, whereas 40% (2/5) undergoing only medical treatment reported resolution of symptoms. Conclusions: Significant reduction in the LLM index occurred after LNF in CF patients after LT that correlated with resolution of clinical symptoms of GE reflux.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalClinical Transplantation
Volume27
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • Aspiration
  • Cystic fibrosis
  • Gastroesophageal reflux
  • Laparoscopic nissen fundoplication
  • Lipid-laden macrophage index
  • Lung transplantation
  • Oil red o stain

ASJC Scopus subject areas

  • Transplantation

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