Reduction of lipid-laden macrophage index after laparoscopic Nissen fundoplication in cystic fibrosis patients after lung transplantation

Don Hayes, Stephen Kirkby, Karen S. Mccoy, Heidi - Mansour, Medhi Khosravi, Heather Strawbridge, Joseph D. Tobias

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Lipid-laden macrophage (LLM) index could be potentially useful in assessing gastroesophageal (GE) reflux and aspiration after lung transplantation (LT) in patients with cystic fibrosis (CF). Methods: A retrospective review of CF patients undergoing LT and/or laparoscopic Nissen fundoplication (LNF) from January 1, 2009, to December 31, 2011, was performed. Results: Seventeen CF patients (nine women), mean (±SD) age 27.9 ± 7.5 yr, underwent LT with mean (±SD) pre-transplant FEV1 of 20.9 ± 5.0% predicted. Seventy percentage (12/17) of patients underwent LNF without complications within 1-2 wk of LT. After LT, but prior to antireflux surgery, there was no significant difference in the mean (±SD) baseline LLM index (154 ± 41 vs. 146 ± 51, p = NS) between patients who were to undergo LNF and patients who did not. After LNF, a significant reduction in the mean (±SD) LLM index occurred following the procedure (154 ± 41-74 ± 54, p < 0.0001) while each patient reported resolution of symptoms of GE reflux, whereas 40% (2/5) undergoing only medical treatment reported resolution of symptoms. Conclusions: Significant reduction in the LLM index occurred after LNF in CF patients after LT that correlated with resolution of clinical symptoms of GE reflux.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalClinical Transplantation
Volume27
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Fundoplication
Lung Transplantation
Cystic Fibrosis
Macrophages
Lipids
Gastroesophageal Reflux
Transplants

Keywords

  • Aspiration
  • Cystic fibrosis
  • Gastroesophageal reflux
  • Laparoscopic nissen fundoplication
  • Lipid-laden macrophage index
  • Lung transplantation
  • Oil red o stain

ASJC Scopus subject areas

  • Transplantation

Cite this

Reduction of lipid-laden macrophage index after laparoscopic Nissen fundoplication in cystic fibrosis patients after lung transplantation. / Hayes, Don; Kirkby, Stephen; Mccoy, Karen S.; Mansour, Heidi -; Khosravi, Medhi; Strawbridge, Heather; Tobias, Joseph D.

In: Clinical Transplantation, Vol. 27, No. 1, 01.2013, p. 121-125.

Research output: Contribution to journalArticle

Hayes, Don ; Kirkby, Stephen ; Mccoy, Karen S. ; Mansour, Heidi - ; Khosravi, Medhi ; Strawbridge, Heather ; Tobias, Joseph D. / Reduction of lipid-laden macrophage index after laparoscopic Nissen fundoplication in cystic fibrosis patients after lung transplantation. In: Clinical Transplantation. 2013 ; Vol. 27, No. 1. pp. 121-125.
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