Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice

Guan Jie Chen, Lucas L. Colombo, Maria C. Lopez, Ronald R Watson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and γ-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalCancer Letters
Volume74
Issue number3
DOIs
StatePublished - Nov 1 1993

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ras Genes
Tumor Necrosis Factor-alpha
Interferons
Mouse mammary tumor virus
Oncogenes
Carcinogens
Immune System

Keywords

  • Oncomouse
  • Tumor necrosis factor
  • V-Ha-ras oncogene
  • γ-Interferon

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice. / Chen, Guan Jie; Colombo, Lucas L.; Lopez, Maria C.; Watson, Ronald R.

In: Cancer Letters, Vol. 74, No. 3, 01.11.1993, p. 147-150.

Research output: Contribution to journalArticle

Chen, Guan Jie ; Colombo, Lucas L. ; Lopez, Maria C. ; Watson, Ronald R. / Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice. In: Cancer Letters. 1993 ; Vol. 74, No. 3. pp. 147-150.
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