Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice

Guan Jie Chen, Lucas L. Colombo, Maria C. Lopez, Ronald R. Watson

Research output: Contribution to journalArticle

4 Scopus citations


Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and γ-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalCancer Letters
Issue number3
StatePublished - Nov 1 1993



  • Oncomouse
  • Tumor necrosis factor
  • V-Ha-ras oncogene
  • γ-Interferon

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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