Reduction-oxidation state and protein degradation in skeletal muscle of fasted and refed rats

J. M. Fagan, M. E. Tischler

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Redox state and protein degradation were measured in isolated muscles of fasted (up to 10 d) and refed (up to 4 d) 7- to 14-wk-old rats. Protein degradation in the extensor digitorum longus muscle, but not in the soleus muscle, was greater in the fasted rats than in weight-matched muscle from fed rats. The NAD couple was more oxidized in incubated and fresh extensor digitorum longus muscles and in some incubated soleus muscles of fasted rats than in weight-matched muscle from fed rats. In the extensor digitorum longus muscle of refed or prolonged fasted rats, protein degradation was slower and the NAD couple was more reduced than in the fed state. Therefore, oxidation of the NAD couple was associated with increased muscle breakdown during fasting, whereas reduction of the NAD couple was associated with muscle conservation and deposition.

Original languageEnglish (US)
Pages (from-to)2028-2033
Number of pages6
JournalJournal of Nutrition
Volume116
Issue number10
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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